Wednesday, November 24, 2010

The role of Epigenetics, rather than DNA, is involved in disease process.
Moreover, it puts the emphasis on compounds in nutrients (eg foods) that is often a determinant factor. (See vid below)

Basically, Epigenetics is about altering cell function with without changing DNA sequencing, and this is achieved by altering diet rich in methyl donors. I am now making a U-Turn, ;) and will be going back to reading up again on Methylation.

There are tons of evidence to show that the Genomics can't be used to determine if one will develop a particular disease. Furthermore, it has failed miserably to design medications specific to Genomics. Add to that, that gene polymorphisms are often open to interpretation and stats.

This means that a gene polymorphism for one type of particular cancer, is also associated with other disease process, but through Epigenetics, in this case, nutrients, can alter the course of disease process (if not too advanced).

Medical doctors are not trained in this field. Nutritionist, biochemists, biomolecular and molecular biology are much more knowledgeable concerning Epigenetics.

That is what it means to me, to prepare the terrain, right at cellular activity. Anything else, IMHO, is superficial, and will not bring long term healing.

This is why I chose Ayurvedic Medicine, which can be compared to Phytochemistry, and closest to repairing to methylation and damaged DNA. In essence. It uses various compounds (60% from fruits) to alter the course of cellular activities. To research methylation and Epigenetics would be too absorbing and time consuming, Ayurvedic, for me, right now is a short cut.

Various acclaimed Institutions and Teaching Hospitals, Vitamins and Supplements, and Sports Companies, as well as a Swiss Pharmaceutical Company are using Ayurvedic Medicine, the latter patented an excellent compound for cardiac dysfunction. Ayurvedic use different terminology, but overall, it is far more than just being a monotherapy. It works on all systems and functions in the body, applying diet and nutrition, psychology, meditation, breathing, spirituality etc..

Ayurvedic Medicine is becoming Westernized, and are slowly selling out. It is leading to being trivialized and corrupted.

Inevitably, this leads to a schism between purists and westernized Ayurvedic Practitoners. But then again, Western Science and Allopathic Medicine is not without polemics.

Professor Jeremy Nicolson has been working on metabolomics since 1980s and other scientists. Concluded was that there are far more metabolism variation than genetic variations.

From MIT:
About the Lecture
Forget cigarette smoking (well, not completely). The really bad news, says Leona Samson, is that by virtue of the act of living, a human body will be exposed to destructive threats from the environment, and from within itself. Charbroiled burgers, sunlight, pollution, and even how our bodies use oxygen all pose what Samson calls “insults” to the DNA of our cells.

Our success in fending off these inevitable DNA-damaging agents in the environment depends a lot on inheritance, Samson tells us. For instance, victims of the rare disease Xeroderma pigmentosum don’t have the capacity to repair DNA that’s been corrupted by UV radiation from the sun. Children with Xeroderma pigmentosum develop skin cancers. In the larger population, such cancers tend to occur much later in life. The reason, Samson says, is that most of us have a formidable array of mechanisms within our cells for detecting and mending defective DNA. Cells with flawed DNA that goes unrepaired must either die, or go on to mutate in often dangerous ways.

Samson wants to figure out how to protect cells against carcinogenic effects in the environment, and whether a tumor cell will be susceptible to treatment. She has been painstakingly studying the Saccharomyces cerevisiae yeast organism, trying to identify all the factors that determine whether or not DNA damaging agents kill or mutate cells. She interrogated each of this organism’s 5,800 genes, “asking one by one, which of you is making a product that’s important to helping a cell recover from damage.” In what was a “huge surprise,” Samson learned that there are more than 2,000 gene products involved in helping a yeast cell repair itself, “from areas of the cell never suspected before for being important” in this way. Now Samson must elucidate the complex cellular pathways that “talk to each other” when DNA is damaged -- and figure out “how to extend to humans, ultimately.”


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List of some Fluoroquinolones Antibiotics

List of some fluoroquinolones antibiotics- for list of symptoms go to: www.fluoroquinolones.org
forum: www.favc.info


Generic & Brand Name of most common Fluoroquinolones

Brand Name: Trovan - Zithromax
Generic Name: Trovafloxacin and Azithromycin

Brand Name: Factive
Generic Name: Gemifloxacin Mesylate

Brand Name: Zagam
Generic Name: Sparfloxacin

Brand Name: Vigamox
Generic Name: Moxifloxacin

Brand Name: Vigamox
Generic Name: Moxifloxacin

Brand Name: Cinobac
Generic Name: Cinoxacin

Brand Name: Penetrex
Generic Name: Enoxacin

Brand Name: Tequin
Generic Name: Gatifloxacin (Removed from US Market - May 2006)

Brand Name: Levaquin
Generic Name: Levofloxacin

Brand Name: Floxin
Generic Name: Ofloxacin

Brand Name: Synercid
Generic Name: Quinupristin and Dalfopristin

Brand Name: Trovan - Zithromax

Brand Name: Zymar
Generic Name: Gatifloxacin Ophthalmic Solution

Brand Name: Avelox
Generic Name: Moxifloxacin HCL

Brand Name: Floxin Otic Singles

Brand Name: Ciprodex
Generic Name: Ciprofloxacin and Dexamethasone

Brand Name: Raxar
Generic Name: Grepafloxacin

Brand Name: Ocuflox
Generic Name: Ofloxacin Ophthalmic

Brand Name: Quixin
Generic Name: Levofloxacin

Brand Name: Cipro
Generic Name: Ciprofloxacin

Brand Name: Proquin XR
Generic Name: Ciprofloxacin Hcl

Brand Name: Requip XL
Generic Name: Ropinirole Extended Release Tablets

Brand Name: Zanaflex
Generic Name: Tizanidine

Brand Name: Noroxin
Generic Name: Norfloxacin

Brand Name: Maxaquin
Generic Name: Lomefloxacin Hcl

Brand Name: Ciloxan Ophthalmic Solution
Generic Name: Ciprofloxacin HCL Ophthalmic Solution

Brand Name: Cipro XR
Generic Name: Ciprofloxacin Extended-Release

Generic Name Norloaxin Brand Name: Noroxin

Generic Name Temafloxacin Brand name Omniflox