Good Detox recipe using various oils and a smoothie.

Watch out for spinach, some amines can exacerbate CNS, as well as tomatoes, chicken skin and other foods already mentioned here on this thread.

Coconut derivatives has salycylates compounds. Apparently, I read, it can interfere with oxygen transport if " they exceed a threshold concentration. They also occur in honey and prawns etc so certain combinations can lead to higher doses."

Aghhhh - such hard work to remain well, and prevent more symptoms!

Permission requested to copy and pasted:

Phospholipid exchange
From DoctorMyhill

* 1 The Recipe from Beverley Gibson
* 2 Using Other Oils

Phospholipid exchange is a technique for supplying the correct proportion of fats and oils in a bioavailable form to replenish cell membranes and membranes within cells.

This technique has been pioneered by Dr Patricia Kane, who has seen remarkable clinical results. She uses intravenous therapy, but good results are also possible with oral therapy. Together with sufferers I am experimenting with techniques to get the best results. The underlying principles are:

1. The basic membrane structure is made up of phosphatidylcholine . The best source of this is lecithin (available as egg, soya or sunflower lecithin). The trouble with lecithin is that it gets digested in the gut instead of being absorbed as phophatidylcholine. We are experimenting with juicing mixes to see if this will reduce the lecithin to tiny micelles, which will allow it to be absorbed as whole molecules.
2. Membranes then need the right proportion of omega 6 to 3 oils, i.e. 4:1. Hemp oil is very close to this ratio at 3.8:1. (Hemp oil is not the same as linseed oil!) So, add in a small amount of sunflower oil, say 5%. This is the equivalent of Patricia Kane's Body Bio-oil as in the recipe below.
3. Small amount of Eskimo oil (not necessaery if you already take VegEPA)
4. The perfect fuel for brain cells is coconut oil, which is rich in medium chain triglycerides.
5. Furthermore providing an abundance of clean oils helps to displace the toxic oils which have accumulated in the brain as a result of polluting heavy metals, pesticides, volatile organic compounds etc. That is to say these fats will also help detoxification.

The Recipe from Beverley Gibson

Here is the juice that I make 3 times daily - it takes around 5 mins. I use a Juice master available from http://www.juicemas ter.com/product. php?id=3

Juice the following:- (I buy organic and get it delivered to my door from Sainsburys)

* 1/2 lime
* 1/4 medium cucumber
* 1 stick of celery
* Handful of spinach
* 1/2 inch of broccoli stem and/or a few broccoli florets.

* Place all above into a blender and add:-

* 1/4 avocado
* Coconut oil 1 dessert spoon (10ml) (Coconut Oil must have been kept in the fridge in order to blend well)
* Lecithin 1 dessert spoon (10ml)
* Hemp oil 1 dessert spoon (10ml)
* Sunflower oil 1/4 teaspoon (1ml)
* 2-4 Ice cubes

Blend everything until smooth, pour and enjoy.
Using Other Oils

The proportion of omega 6 to 3 in other oils are as follows:

1. Peanut oil - very high!
2. Safflower oil - 152
3. Sunflower oil - 68
4. Corn oil - 54
5. Olive oil - 10
6. Palm oil - 10
7. Soybean oil - 7.7
8. Hemp oil 3.8
9. Canola oil - 2
10. Rapeseed oil - 2
11. Linseed oil - 0.3

You should aim for 4:1 ratio, so if you cannot access hemp oil or there is an allergy problem, make up another mix. So, for example 80% olive oil with 20% linseed oil would also give a 4:1 ratio.

Glutathione - brief review

Reading assiduously about raising glutathione leads me to conclude that the safest option is by taking its precursors such as Black Seed Oil, which apparently, can raise Glutathione by 800% , or Rosemary Edible OIl by 400% together with Vitamins C, E, Selenium, Zinc, and riboflavins.

Black seed oil has properties which are also anti-mutagenic, immune enhancer, anti fungal, and is even being studied for reversing cancer, chemopreventive and more.

It scavenges Nitric Oxide, decreases cholesterol, and blood lipid peroxide, has anti-inflammatory properties on vascular cells, induces leukemia cell apoptosis, and chemo preventive amongst other benefits.

See 3272 studies on PubMed: http://www.ncbi.nlm.nih.gov/sites/entrez

and here: http://www.lef.org/prod_hp/abstracts/php-ab469.html

Rosemary Edible Oil is not to be taken long term. It is very potent and a powrerful antioxidant being fat soluble, it helps detoxify the brain, helping the central nervous system. It also holds anti-cancerous compounds. It is excellent for cognition, helps boosting memory, cognition, oxygenate blood flow to the brain.

In addition, it has antiviral properties, helps restore liver function from toxic chemicals.

Studies show it stimulates bile function leading to the liver getting rid of chemical toxins. Note that bile plays an important role in nutrition.

Rosemary is also effective for digestive issues, is an immune modulator, and known to help with brain circulation.

It is also effective as an analgesic and arthritis.

Moreover, it is anti-mutagenic, and will help fight toxic chemicals restoring gene function!! It can be used against radiation as when exposed to scans, ionic x-rays etc..

See 874 studies on PubMed: http://www.ncbi.nlm.nih.gov/sites/entrez

Milk thistle if tolerated can stimulate the liver to rasie glutathione, but should not be taken for longer than two weeks, then stop the Milk thistle, and start again. It not a viable option, and may even cause toxicity in the long term.

The decision and responsibility to take Glutathione ultimately lies with you. Clear analysis and critical thinking is of value when deciding which approach to take.

There are contradictions about the use of Glutathione, whilst, many alternative doctors are using this frequently as an adjunct therapy, be aware of the risks. Few alternative doctors are putting the patient first. Most are not up to date with the research, not treating the patient as individuals, using therapies in many instances that are unsuitable.

Early on, I chose to take ImmunoPro - undenatured when protein, containing amino acids and bonded ceystine. Another product which has excellent endorsement from the medical community is called "Immunocal." Many I know reacted to this. It is recommended to start with a tiny quantity and increase over a period fo time. According to a well known CFS doctor, ImmunoPro works well and is gentler than Immunocal. Milk thistle and various other compounds are known to raise Glutathione.

It can be bought in capsules forms, (liposomal), sublingual, spray, transdermal patches, cream or IV.

I didn't think, based on my research, that it was safe to boost Glutathione level, for me, unless done over a period of time. If the digestive system, liver and kidneys are not functioning optimally, in particular Liver Detox Pathway I & II, it made no sense to raise Glutathione, rather than working as an antioxidant, it was likely it would turn into an oxidant and cause even more free radical damage.

It can also be harmful to those on Anti-depressants or with severe CNS symptoms. Again, do your research, be cautious.

Some foods that are known to raise Glutathione: broccoli, cabbage, avocado, artichokes, brussel spouts.

The simplest and easiest read about Glutathione below:

RAISING GSH LEVELS

If glutathione is manufactured within the body, what can we do to maintain or increase GSH levels? Some pharmaceutical drugs can do it, and so can some natural sources. Eating glutathione cannot. There are many ideas about how to raise GSH levels in the body but only a few actually work – and some of them have side effects. In order to take advantage of the great potential of GSH in health and disease we must dispel the myths and clarify the facts. This requires an understanding of the biochemical makeup of this important protein.

GSH is a tripeptide – a protein made up of three amino acids – in this case, glycine, glutamate (glutamic acid), and cysteine. The chemical structure of glutathione does not easily survive the digestive process, so eating it will not raise GSH levels. The body manufactures it within the cell from building blocks (precursors) of GSH in our food. Glycine and glutamate are readily available in North American diets, but cysteine-containing proteins are much harder to come by. Figure 12 shows sources of these three component amino-acids of glutathione.

Cysteine – a sulfur-containing, or "thiol" amino acid – is responsible for the biological activity (bioactivity) of the whole molecule. Cysteine as an isolated amino acid has trouble getting from your mouth to your cells. Much of it is broken down or altered in the digestive tract and bloodstream. So we must take cysteine in a form that resists breakdown. If the body doesn’t get these sulfur-containing amino acids into the blood, we can’t make GSH.

Other thiol amino acids include cystine (different from cysteine) and methionine. Cystine is known as a "disulfide" amino acid because it contains two cysteine molecules connected by their sulfur atoms – a so-called dilsulfide bridge. Cystine is not generally found as a free amino acid. Methionine may serve as a glutathione building block, but it has the tendency to convert into homocysteine, which raises the risk of heart disease.

There are several ways to raise GSH levels. Both pharmaceutical and natural products are listed in figure 13 and described in this chapter. We also describe how GSH as a whole works with other nutrients or co-factors.

Cont/... http://www.msmusings.com/archive81/FYI,%20raising%20glutathione%20levels.htm

What is Glutathione, why is it an intergral part of Recovery?

Simplified summary:

Glutathione is a major antioxidant, fighting disease process, by reducing free radicals activity. Many suffering physiological trauma such as from Vaccines, ADRs from medications, in particular CNS symptoms from neurotoxicity, ensuing disease process, either environmental or iatrogenic, resulting in oxidative stress, have very low Glutathione or dysfunctional GTSM1 Glutathione Transferase CYP Enzyme.

The mechanism involving Reactive Oxygen Species (ROS) plays a very important role in cell metabolism, cell signalling, BUT, if there is accumulation of free radicals, as well as dysfunctional detoxification Pathway I and Pathway II in the liver, it may result in cell death, and ensuing disease process over the years.

Nitric Oxide, (NO) a free radical, if allowed to accumulate, also contributes to disease process over a period of time, including, worsening of symptoms from neurotoxicity.

NO plays a major role in neurotoxicity, as well as the immune system, and physiology/biochemistry.

Scientists over the years, have focused on devising protocols to help lowering cell death from a rise in NO, and ROS. The general consensus is that there is if ROS is not kept under control, cell death and mutation will lead to inflammatory process and disease state.

Raising Glutathione and taking antioxidants are crucial in assisting recovery from ADRs.

Those undergoing chemotherapy in Germany, are also administered Glutathione IV, to avoid toxicity. If unable to tolerate Glutathione IV, other protocols such as N-acetylcysteine (NAC), a precursor of GSH, Alpha-Lipoic Acid (ALA), Vitamin C, Selenium, and Zinc, are gentler options.

NAC is often administered in hospitals to those suffering from dysfunctional/failing kidneys prior to contrast dye and other radioactive compounds to avoid toxicity.

The next post will include more information on Glutathione, AntiOxidants, gentle detox protocols, and the role of prevention through managing ROS and other Free Radicals.

Some research below, concerning the above.

http://www.ncbi.nlm.nih.gov/pubmed/19662025?ordinalpos=55&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
or
http://tinyurl.com/ygglddw

http://www.ncbi.nlm.nih.gov/pubmed/19715735?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
or
http://tinyurl.com/yktxlkl

http://www.ncbi.nlm.nih.gov/pubmed/16444668?ordinalpos=23&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
or

http://tinyurl.com/yf6rhwe


http://www.ncbi.nlm.nih.gov/pubmed/19782114?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
or
http://tinyurl.com/yzdpodz


http://www.ncbi.nlm.nih.gov/pubmed/19689380?ordinalpos=49&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
or
http://tinyurl.com/yjpo8r8

What is Glutathione by Dr Mark Hyman

Detoxing, gently, safely!!

Ill for 13 years post ADRs, It is only last year, that I have been able to start (with great difficulties) on a protocol for methylation, mitochondria (diagnosed with mitochondrial dysfunction), detoxing, diet and nutrition. Progress is hampered by severe allergies, MCS, and severe CYPs (enzymes in the digestive system, kidneys, liver and brain, all connected) dysfunction.

It is not possible, to swallow a whole vitamin, even at the lowest dosage, unless trying tiny crumbs from each, tablet, lasting several days/weeks, building up to tolerance level.

I am very restricted in what I can take concerning vits and supps. However, raising the glutathione by taking its precursors, and attempting to take anti-oxidants, is yielding results in some areas.

There is some improvement in some areas, whilst not in vascular, cardiac, liver function and severe weakness. Difficult to quantify, at this time.

Those I personally know who applied themselves to raising glutathione, tajung anti-oxidants, some gently, over a period of time, some more aggressively by taking NAC, ALA, selenium and Vit C, others doing Glutathione IV, have all benefited, without side effects.

Some have reacted to Glutathione IV, depending their own health status, and medications, sensitivities, and allergies.

"The Detox System: Detoxification of Biotoxins in Chronic Neurotoxic Syndromes"

By John Foster, M.D., Patricia Kane, Ph.D., Neal Speight, M.D.

Chronically ill individuals suffering from neurotoxin exposure impacts patient populations with CFIDS, Fibromyalgia, MS, Autism, Cardiovascular Disease, Depression, Rheumatoid Arthritis, IBS, Infertility, ALS, Parkinsons, Lyme, Toxic Building Syndrome, Estuary Associated Syndrome, Psychosis, Diabetes without family Hx, Optic Neuritis, Refractory Heavy Metal Toxicity, Pulmonary Hemorrhage, Stroke. Patients diagnosed with these chronic illnesses may be potentially classified as 'Neurotoxic Membrane Syndrome' (NMS) with the endothelial cell membrane as the target of degeneration.


While hypercoagulation involves a myriad of proteins, it is ultimately a membrane event, essentially disrupting the phospholipids that structure the membrane. Agglomeration (blocked cellular exposure to blood flow/nutrients and impaired cell-to-cell communication) indicates elevation of phospholipase A2 and the uncoupling of eicosanoids from the cell membrane causing inflammation. The agglomeration that eventually occurs is, in essence, a product of a weakened membrane, and ultimately a disturbed red cell fatty acid profile.


Clinical Research

We have established a biomedical protocol in our clinics, The Haverford Wellness Center in Havertown, PA and The Center for Wellness in Charlotte, NC for patients with neurotoxic illness. Our biomedical approach is an attempt to reach the systemic nature of these tenacious neurotoxic syndromes and provide clinically proven methods that eradicate neurotoxins. Our course of action is that of freeing the patient of pervasive symptoms of neurotoxic illness in a noninvasive manner that heals the membrane, and ultimately the body and brain.

The recent pioneering work of Ritchie Shoemaker, M.D., as communicated in his book Desperation Medicine and his peer reviewed papers (Shoemaker 2001), lends strong support to a connection between Chronic Fatigue Syndrome, Fibromyalgia, Lyme Disease, Pfiesteria infection and that of numerous Neurotoxic Syndromes.

Biotoxins as Neurotoxins

The presentation of biotoxin exposure often parallels neurological and psychological impairment due to the interrelationship between the ENS (Enteral Nervous System) and the CNS. The biliary tree, gall bladder, and bile formation within the liver serve in the vital processes of detoxication (disposal of waste products bilirubin, heavy metals, biotoxins, xenobiotics), lipid metabolism, transport and digestion (bile acids). Abnormalities of the hepatobiliary system may involve biliary stasis whereby infectious material or biotoxins reside within the liver, biliary tree and gall bladder, as a viscous suspension in biliary sludge.

Biotoxins as bacteria, viruses, parasites, spirochetes, dinoflagelletes, and fungus may be within biliary sludge often creating neurotoxins impacting the CNS via the ENS, or the Second Brain (gut). The occurrence of biliary sludge may be due to prolonged fasting, low fat intake, high carbohydrate diets or exposure to pathogens. Restriction of dietary fat may impair biliary flow which would be contraindicated in attempting to clear toxicity as bile is paramount to cleansing the body and getting biotoxins and heavy metals excreted into the fecal matter.

Neurotoxins are minute compounds between 200-1000 KD (kilodaltons) that are comprised of oxygen, nitrogen and sulfate atoms arranged in such a way as to make the outside of the molecule fat loving and water hating. As such, once it enters the body, it tends to bind to structures that are rich in fat such as most of our cells, especially the liver, kidney, and brain. Neurotoxins are capable of dissolving in fatty tissue and moving through it, crossing cell membranes (transporting against a gradient, particularly with potassium) disrupting the electrical balance of the cell itself.

As fat soluble neurotoxins move through the cells of the body from the GI tract to sinus to lung to eye to muscle, to joint to nerve, whereby they eventually enter the liver and the bile. Once neurotoxins bind with bile they have access to the liver, the body is poisoned over and over again as the bile is re-circulated (first released into the intestine to digest fats, and then reabsorbed).

Neurotoxins cause damage by disrupting sodium and calcium channel receptors, attacking enzyme reactions involved in glucose production thereby disrupting energy metabolism in the cell, manufacturing renegade fatty acids as saturated very long chain, odd chain and branched chain fatty acids impairing membrane function, stimulating enzymes (PLA2) which uncouple essential fatty acids from the cell membrane and impairing the function of the nuclear receptor PPAR gamma which partially controls transcription (the conversion of instructions held in our DNA to RNA which then leads to translation or protein production in the cell).

Heavy Metals reside in Fatty Tissue with Biotoxins

Heavy metals are also lipid soluble and often compound the removal of biotoxins (Aschner et al 1990, 1998; Dutzak 1991). As has been observed by many clinicians, often as the patients' heavy metal toxicity is addressed they are faced with the additional complication of the presence of biotoxins. Biotoxins and heavy metal exposure co-exist within the cell membrane and fatty tissue requiring consideration for both types of toxicity in regard to patient intervention.

By stabilizing glutathione we in turn impact metallothionein markers (Nordberb and Nordberb 2000, Ebadi et al 1995, Sato et al 1995, Kerper et al 1996, Susanto et al 1998), glycoaminoglycans or GAGS (Klein 1992), methylation, sulfation, hepatic and renal function as we introduce treatment protocols for detoxication with gentle, natural modalities that unload cellular toxicity safely. GSH infusion by fast IV push has been a remarkable tool to unload the body burden of heavy metals and neurotoxins in both pediatric and adult populations, without side effects.

Cont/..
http://tinyurl.com/yql6ad

Glutathione -- Powerful anti oxidant

There will be more detailed article concerning glutathione. There are so many theories concerning this.

Ascorbate acid at 2500 mg x 2 daily will help raise glutathione.

Likewise, NAC, ALA, selenium and Vitamin C, will also raise glutathione.

But, what is it exactly?