What is Glutathione, why is it an intergral part of Recovery?

Simplified summary:

Glutathione is a major antioxidant, fighting disease process, by reducing free radicals activity. Many suffering physiological trauma such as from Vaccines, ADRs from medications, in particular CNS symptoms from neurotoxicity, ensuing disease process, either environmental or iatrogenic, resulting in oxidative stress, have very low Glutathione or dysfunctional GTSM1 Glutathione Transferase CYP Enzyme.

The mechanism involving Reactive Oxygen Species (ROS) plays a very important role in cell metabolism, cell signalling, BUT, if there is accumulation of free radicals, as well as dysfunctional detoxification Pathway I and Pathway II in the liver, it may result in cell death, and ensuing disease process over the years.

Nitric Oxide, (NO) a free radical, if allowed to accumulate, also contributes to disease process over a period of time, including, worsening of symptoms from neurotoxicity.

NO plays a major role in neurotoxicity, as well as the immune system, and physiology/biochemistry.

Scientists over the years, have focused on devising protocols to help lowering cell death from a rise in NO, and ROS. The general consensus is that there is if ROS is not kept under control, cell death and mutation will lead to inflammatory process and disease state.

Raising Glutathione and taking antioxidants are crucial in assisting recovery from ADRs.

Those undergoing chemotherapy in Germany, are also administered Glutathione IV, to avoid toxicity. If unable to tolerate Glutathione IV, other protocols such as N-acetylcysteine (NAC), a precursor of GSH, Alpha-Lipoic Acid (ALA), Vitamin C, Selenium, and Zinc, are gentler options.

NAC is often administered in hospitals to those suffering from dysfunctional/failing kidneys prior to contrast dye and other radioactive compounds to avoid toxicity.

The next post will include more information on Glutathione, AntiOxidants, gentle detox protocols, and the role of prevention through managing ROS and other Free Radicals.

Some research below, concerning the above.

http://www.ncbi.nlm.nih.gov/pubmed/19662025?ordinalpos=55&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
or
http://tinyurl.com/ygglddw

http://www.ncbi.nlm.nih.gov/pubmed/19715735?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
or
http://tinyurl.com/yktxlkl

http://www.ncbi.nlm.nih.gov/pubmed/16444668?ordinalpos=23&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
or

http://tinyurl.com/yf6rhwe


http://www.ncbi.nlm.nih.gov/pubmed/19782114?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
or
http://tinyurl.com/yzdpodz


http://www.ncbi.nlm.nih.gov/pubmed/19689380?ordinalpos=49&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
or
http://tinyurl.com/yjpo8r8

What is Glutathione by Dr Mark Hyman

Detoxing, gently, safely!!

Ill for 13 years post ADRs, It is only last year, that I have been able to start (with great difficulties) on a protocol for methylation, mitochondria (diagnosed with mitochondrial dysfunction), detoxing, diet and nutrition. Progress is hampered by severe allergies, MCS, and severe CYPs (enzymes in the digestive system, kidneys, liver and brain, all connected) dysfunction.

It is not possible, to swallow a whole vitamin, even at the lowest dosage, unless trying tiny crumbs from each, tablet, lasting several days/weeks, building up to tolerance level.

I am very restricted in what I can take concerning vits and supps. However, raising the glutathione by taking its precursors, and attempting to take anti-oxidants, is yielding results in some areas.

There is some improvement in some areas, whilst not in vascular, cardiac, liver function and severe weakness. Difficult to quantify, at this time.

Those I personally know who applied themselves to raising glutathione, tajung anti-oxidants, some gently, over a period of time, some more aggressively by taking NAC, ALA, selenium and Vit C, others doing Glutathione IV, have all benefited, without side effects.

Some have reacted to Glutathione IV, depending their own health status, and medications, sensitivities, and allergies.

"The Detox System: Detoxification of Biotoxins in Chronic Neurotoxic Syndromes"

By John Foster, M.D., Patricia Kane, Ph.D., Neal Speight, M.D.

Chronically ill individuals suffering from neurotoxin exposure impacts patient populations with CFIDS, Fibromyalgia, MS, Autism, Cardiovascular Disease, Depression, Rheumatoid Arthritis, IBS, Infertility, ALS, Parkinsons, Lyme, Toxic Building Syndrome, Estuary Associated Syndrome, Psychosis, Diabetes without family Hx, Optic Neuritis, Refractory Heavy Metal Toxicity, Pulmonary Hemorrhage, Stroke. Patients diagnosed with these chronic illnesses may be potentially classified as 'Neurotoxic Membrane Syndrome' (NMS) with the endothelial cell membrane as the target of degeneration.


While hypercoagulation involves a myriad of proteins, it is ultimately a membrane event, essentially disrupting the phospholipids that structure the membrane. Agglomeration (blocked cellular exposure to blood flow/nutrients and impaired cell-to-cell communication) indicates elevation of phospholipase A2 and the uncoupling of eicosanoids from the cell membrane causing inflammation. The agglomeration that eventually occurs is, in essence, a product of a weakened membrane, and ultimately a disturbed red cell fatty acid profile.


Clinical Research

We have established a biomedical protocol in our clinics, The Haverford Wellness Center in Havertown, PA and The Center for Wellness in Charlotte, NC for patients with neurotoxic illness. Our biomedical approach is an attempt to reach the systemic nature of these tenacious neurotoxic syndromes and provide clinically proven methods that eradicate neurotoxins. Our course of action is that of freeing the patient of pervasive symptoms of neurotoxic illness in a noninvasive manner that heals the membrane, and ultimately the body and brain.

The recent pioneering work of Ritchie Shoemaker, M.D., as communicated in his book Desperation Medicine and his peer reviewed papers (Shoemaker 2001), lends strong support to a connection between Chronic Fatigue Syndrome, Fibromyalgia, Lyme Disease, Pfiesteria infection and that of numerous Neurotoxic Syndromes.

Biotoxins as Neurotoxins

The presentation of biotoxin exposure often parallels neurological and psychological impairment due to the interrelationship between the ENS (Enteral Nervous System) and the CNS. The biliary tree, gall bladder, and bile formation within the liver serve in the vital processes of detoxication (disposal of waste products bilirubin, heavy metals, biotoxins, xenobiotics), lipid metabolism, transport and digestion (bile acids). Abnormalities of the hepatobiliary system may involve biliary stasis whereby infectious material or biotoxins reside within the liver, biliary tree and gall bladder, as a viscous suspension in biliary sludge.

Biotoxins as bacteria, viruses, parasites, spirochetes, dinoflagelletes, and fungus may be within biliary sludge often creating neurotoxins impacting the CNS via the ENS, or the Second Brain (gut). The occurrence of biliary sludge may be due to prolonged fasting, low fat intake, high carbohydrate diets or exposure to pathogens. Restriction of dietary fat may impair biliary flow which would be contraindicated in attempting to clear toxicity as bile is paramount to cleansing the body and getting biotoxins and heavy metals excreted into the fecal matter.

Neurotoxins are minute compounds between 200-1000 KD (kilodaltons) that are comprised of oxygen, nitrogen and sulfate atoms arranged in such a way as to make the outside of the molecule fat loving and water hating. As such, once it enters the body, it tends to bind to structures that are rich in fat such as most of our cells, especially the liver, kidney, and brain. Neurotoxins are capable of dissolving in fatty tissue and moving through it, crossing cell membranes (transporting against a gradient, particularly with potassium) disrupting the electrical balance of the cell itself.

As fat soluble neurotoxins move through the cells of the body from the GI tract to sinus to lung to eye to muscle, to joint to nerve, whereby they eventually enter the liver and the bile. Once neurotoxins bind with bile they have access to the liver, the body is poisoned over and over again as the bile is re-circulated (first released into the intestine to digest fats, and then reabsorbed).

Neurotoxins cause damage by disrupting sodium and calcium channel receptors, attacking enzyme reactions involved in glucose production thereby disrupting energy metabolism in the cell, manufacturing renegade fatty acids as saturated very long chain, odd chain and branched chain fatty acids impairing membrane function, stimulating enzymes (PLA2) which uncouple essential fatty acids from the cell membrane and impairing the function of the nuclear receptor PPAR gamma which partially controls transcription (the conversion of instructions held in our DNA to RNA which then leads to translation or protein production in the cell).

Heavy Metals reside in Fatty Tissue with Biotoxins

Heavy metals are also lipid soluble and often compound the removal of biotoxins (Aschner et al 1990, 1998; Dutzak 1991). As has been observed by many clinicians, often as the patients' heavy metal toxicity is addressed they are faced with the additional complication of the presence of biotoxins. Biotoxins and heavy metal exposure co-exist within the cell membrane and fatty tissue requiring consideration for both types of toxicity in regard to patient intervention.

By stabilizing glutathione we in turn impact metallothionein markers (Nordberb and Nordberb 2000, Ebadi et al 1995, Sato et al 1995, Kerper et al 1996, Susanto et al 1998), glycoaminoglycans or GAGS (Klein 1992), methylation, sulfation, hepatic and renal function as we introduce treatment protocols for detoxication with gentle, natural modalities that unload cellular toxicity safely. GSH infusion by fast IV push has been a remarkable tool to unload the body burden of heavy metals and neurotoxins in both pediatric and adult populations, without side effects.

Cont/..
http://tinyurl.com/yql6ad

Navy Soldiers die after receiving Swine Flu Shot

(MY own personal view, is that, figures being published concerning deaths attributed to swine flu are highly questionable, according to polls, so does a high percentage of the population.

Few trust the reporting system, after all, we suffered serious life threatening ADRs from toxic medications, and vaccines, and still - being denied the toxicity diagnosis. How can any regulatory healthy institutions be trusted??


Courtesy of Bob Chapman of The International Forecaster

Subject: Vital data about US Navy results of swine flu vaccine on ship

Data gleaned indirectly from anonymous testimony of Navy wives of the affected crew via the internet radio show A Marine Disquisition http://www.clipser.com/watch_video/1362067 :

1. Unnamed US Navy vessel put to sea in April with 347 man crew.
2. Entire crew was vaccinated with H1N1 Swine Flu vaccine shortly after they put to sea.
3. Crew sickened so severely that other ships had to respond to render aid. 16 Medical Dr.s put aboard from an unnamed aircraft carrier and other responding vessels. Total of 50 Navy personnel sent aboard to respond to crisis.
4. Two of the crew of 347 died – including the Captain of the ship (a Lieutenant Commander) and a Chief Petty Officer.
5. 50 personnel sent aboard to help are quarantined in Navy hospital in Balboa, Spain after 10 of them caught the flu from the ship’s crew. Two of the 50 quarantined are in serious condition at last report.
6. Of the 347 man crew that were vaccinated, 333 contracted the H1N1 flu FROM THE VACCINE. Two died, as mentioned above, and 331 survived. Only 14 of the 347 vaccinated sailors did not show any ill effects from the vaccine.
7. Navy has threatened all the spouses of the ship’s crew to remain silent – claiming all this information is classified. Some are whistle-blowing and that is where this information is coming from.
8. On the unnamed aircraft carrier that provided assistance, 415 sailors contracted the swine flu and are currently quarantined onboard.

PLEASE pass this email along. The truth is that the swine flu epidemic will be created BY THE VACCINE. If we don’t take it, there will be no epidemic. From this one test it’s apparent that the vaccine as tested on that ship’s crew in April is 96% effective at infecting the recipient with swine flu. Such an infection rate is impossible to achieve by any natural means. Though it only killed 1% immediately, there is no telling what the long term effects on those injected with the vaccine will be. See the research on the long term effects of the 1976 swine flu vaccine, and the Gulf War anthrax vaccine programs for more information.

Also note that mere contact with those that have been vaccinated creates a 20% chance of you contracting the swine flu even if you have not been vaccinated.

Please pass this data along to anyone you care about!

http://www.cbsnews.com/stories/2009/07/21/health/main5177494.shtml
http://www.resistnet.com/profiles/blogs/navy-soldiers-are-dying-from

VIDEO: Navy Soldiers are dying from swine flu shot




CAPTAIN, CPO DEAD AFTER SWINE FLU SHOTS

	Re: Swine flu cover up « Reply #19 Today at 9:13am »
Navy Soldiers die after receiving Swine Flu Shot Official figures of deaths attributed to H1N1 swine flu, are highly questionable. My own personal belief, and that of many, find those figures unconvincing and propaganda. Likewise, deaths following swine flu shots are being kept under wraps!! There is no conflict of interest here, except exposing the truth. Courtesy of Bob Chapman of The International Forecaster Subject: Vital data about US Navy results of swine flu vaccine on ship Data gleaned indirectly from anonymous testimony of Navy wives of the affected crew via the internet radio show A Marine Disquisition http://www.clipser.com/watch_video/1362067 : 1. Unnamed US Navy vessel put to sea in April with 347 man crew. 2. Entire crew was vaccinated with H1N1 Swine Flu vaccine shortly after they put to sea. 3. Crew sickened so severely that other ships had to respond to render aid. 16 Medical Dr.s put aboard from an unnamed aircraft carrier and other responding vessels. Total of 50 Navy personnel sent aboard to respond to crisis. 4. Two of the crew of 347 died – including the Captain of the ship (a Lieutenant Commander) and a Chief Petty Officer. 5. 50 personnel sent aboard to help are quarantined in Navy hospital in Balboa, Spain after 10 of them caught the flu from the ship’s crew. Two of the 50 quarantined are in serious condition at last report. 6. Of the 347 man crew that were vaccinated, 333 contracted the H1N1 flu FROM THE VACCINE. Two died, as mentioned above, and 331 survived. Only 14 of the 347 vaccinated sailors did not show any ill effects from the vaccine. 7. Navy has threatened all the spouses of the ship’s crew to remain silent – claiming all this information is classified. Some are whistle-blowing and that is where this information is coming from. 8. On the unnamed aircraft carrier that provided assistance, 415 sailors contracted the swine flu and are currently quarantined onboard. PLEASE pass this email along. The truth is that the swine flu epidemic will be created BY THE VACCINE. If we don’t take it, there will be no epidemic. From this one test it’s apparent that the vaccine as tested on that ship’s crew in April is 96% effective at infecting the recipient with swine flu. Such an infection rate is impossible to achieve by any natural means. Though it only killed 1% immediately, there is no telling what the long term effects on those injected with the vaccine will be. See the research on the long term effects of the 1976 swine flu vaccine, and the Gulf War anthrax vaccine programs for more information. Also note that mere contact with those that have been vaccinated creates a 20% chance of you contracting the swine flu even if you have not been vaccinated. Please pass this data along to anyone you care about! http://www.cbsnews.com/stories/2009/07/21/health/main5177494.shtml http://www.resistnet.com/profiles/blogs/navy-soldiers-are-dying-from VIDEO: Navy Soldiers are dying from swine flu shot CAPTAIN, CPO DEAD AFTER SWINE FLU SHOTS http://www.cbsnews.com/stories/2009/07/21/health/main5177494.shtml http://www.resistnet.com/profiles/blogs/navy-soldiers-are-dying-from http://theplaintruth.websitetoolbox.com/post?id=3686614

Propaganda and instilling fear continues unabated, except for attempts by some honest medical practitioners. Yet, the general population appear to focus on the "epidemic", rather than the rationale for spreading fear. It is advised to all, to research are read up on the massive profits involved as well as population reduction. Similar stratagem was used in 1918 during the "manufactured" Spanish Flu virus. The only EU country which suffered [Edit] very few[Edit] deaths, death from Spanish Flu, in 1918, were the Greeks. Some say it is because they did not undergo vaccination program, others say there were no vaccines at the time except for smallpox. The point is the scientists identified viruses for the first time in 1933!!

Swine Flu vaccine and Lung Cancer

German Health expert's swine flu warning Does virus increase the risk of cancer?

The swine flu vaccine has been hit by new cancer fears after a German health expert gave a shock warning about its safety.

Lung specialist Wolfgang Wodarg has said that there are many risks associated with the vaccine for the H1N1 virus.

He has grave reservations about the firm Novartis who are developing the vaccine and testing it in Germany. The vaccination is injected “with a very hot needle”, Wodarg said.

The nutrient solution for the vaccine consists of cancerous cells from animals and "we do not know if there could be an allergic reaction".

But more importantly, some people fear that the risk of cancer could be increased by injecting the cells.

The vaccine - as Johannes Löwer, president of the Paul Ehrlich Institute, has pointed out - can also cause worse side effects than the actual swine flu virus.

Wodrag also described people’s fear of the pandemic as an "orchestration": “It is great business for the pharmaceutical industry,” he told the ‘Neuen Presse’.

Swine flu is not very different from normal flu. “On the contrary if you look at the number of cases it is nothing compared to a normal flu outbreak,” he added. Cont/.....

http://tinyurl.com/llmfff

Florida Quarantine Order Documents

September 2, 2009

Here is some Important Must see documents for anybody living in the Florida State !!!

These PDF files are hosted on the Centers for Disease Control website.

What and where are the detention quarantine secure facilities???

http://www2a.cdc.gov/phlp/docs/FL%20Quarantine%20To%20Detention%20Facility%20Order%20Apr%2009%20252.pdf

http://www2a.cdc.gov/phlp/docs/FL%20Quarantine%20To%20Residence%20Order%20Apr%2009%20252.pdf

http://www2a.cdc.gov/phlp/docs/FL%20Quarantine%20Of%2

0Facility%20Order%20Apr%2009%20252.pdf

Detention (Quarantine) Centers, Forced Vaccinations, Mass Graves being prepared in the UK, hum, propaganda heats up.

H1N1 Swine Flu: Forced Vaccinations in Massachusetts
September 1, 2009
H1N1 Flu
Article from Global Research

http://www.mass.gov/legis/bills/senate/186/st02pdf/st02028.pdf

The legislation for forced vaccination in Massachusetts (Mass. Senate Bill)

http://www.mass.gov/legis/bills/senate/186/st02pdf/st02028.pdf


or

http://www.scribd.com/doc/17532372/Massachusetts-S18-Swine-Flu-Home-Entry


http://atomicnewsreview.org/

Watch this vid, what more can be said...


Makers of Vaccines Refuse to take H1N1







Journalist Wayne Madsen tells Russia today scientists involved in creating previous vaccinations are telling family and friends not to take the H1N1 vaccine. Madsen also warns that the government may make the vaccination mandatory.

H1N1 (Swine Flu) scaremongering tactics

There is a need to analyze, and be informed of the scaremongering tactics of governmental agencies and WHO health officials.

In order to redress this, please read this and preceding articles.

Scientists and doctors worldwide are protesting against this vaccine, openly speaking up about its dangers and inefficacy. Read the next article, Australia and protesting scientists!!

Analyzing the propaganda by WHO and governmental officials, the "pandemic" seems to be nothing more than scaremongering.

Oh, and did I mention, pigs can fly?

Don't inject me song by Mike Adams, the Health Ranger

Rap with the Viral Attack




It is impossible to estimate those affected with swine flu in the UK (and elsewhere). A help line was set up, people being diagnosed over the phone based on reporting sore throat, flu like symptoms and slight temperature. They were told to collect Tamifu!!!

Statistical manipulation is obvious and crude in this particular instance!!

Sinister, how will anyone know what is happening to those who are quarantined under civilian and/or military jurisdiction in the USA? What assurance of their "safety?"

Remember that during the Spanish Flu "pandemic" Greece was the only EU country at the time to refuse mass vaccination program which resulted in ZERO death from Spanish Flu.

Reading preceding articles concerning the manipulation and gross misconduct of health officials, leads to one conclusion: [b]PROPAGANDA and POPULATION CONTROL[/b]!!

Be very aware, and make an "informed" decision concerning the vaccine.

The H1N1 Swine Flu Pandemic: Manipulating the Data to Justify a Worldwide Public Health Emergency

by Michel Chossudovsky

"If the information is conceptually incorrect or incomplete at the outset, predictions and/or simulations will be inevitably be biased.

Without systematic lab confirmation, it is impossible to specify the nature of the virus because the symptoms of H1N1 are broadly similar to those of common influenza. In other words, do the data collected and transmitted by the states to the CDC confirm cases of H1N1 swine flu or do they indicate the prevalence of seasonal influenza?

The CDC posits that the data sent to them by the states is "underestimated". It then hikes up these figures of "unconfirmed" cases, many of which are cases of seasonal influenza. The "corrected figures" are then inserted into the model:

Using this approach [CDC model], it is estimated that more than one million people became ill with novel H1N1 flu between April and June 2009 in the United States. The details of this model and the modeling study will be submitted for publication in a peer reviewed journal. (Ibid)

The model is then used to predict the spread of swine flu and to justify a national health emergency. "Swine flu could strike up to 40 percent of Americans over the next two years and as many as several hundred thousand could die if a vaccine campaign and other measures aren't successful." (Official Statement of the US Administration, Associated Press, 24 July 2009).

Anybody who is familiar with model building and computer simulations, is acutely aware that if the data and assumptions which are fed into the model are incorrect at the outset, the results will inevitably be biased.

What we are dealing with is a process of statistical manipulation, which has far-reaching implications and which could potentially create an atmosphere of panic, particularly if it is coupled, as in the UK, with announcements that "mass graves are being set up to deal with a rising death toll."

......Based on the model's "predictions", mass vaccination of half of the US population is required, with the possible provision for quarantines under civilian and/or military jurisdiction. In the case of the United Kingdom, confirmed by British press reports, the government has predicted a rising death toll requiring the provision of mass graves.

http://www.globalresearch.ca/index.php?context=va&aid=14901

Doctors warn "Swine Flu" vaccines poses too many risks, (from Australia).

MARK COLVIN: The country's top infectious diseases body has written to the Government to warn that the swine flu vaccine is being distributed too hastily, with too many risks for the public.

The Australasian Society for Infectious Diseases says the vaccine will come in multi-dose vials.

It says these have been shown to transmit infection, spread HIV and hepatitis and even cause death.

The Federal Health Minister Nicola Roxon says the Government expects to receive two million doses by the end of next week, and a widespread immunisation program could start by mid-September.

But the infectious diseases doctors say the swine flu threat has now passed, and there's no need for urgent mass vaccination.

Dina Rosendorff reports

DINA ROSENDORFF: It's unusual to hear a doctor speak out like this:

TOM GOTTLIEB: To rush to a massive vaccination using multi-dose vials that have been associated with problems in the past, seems too hasty and perhaps not measured enough for our society.

DINA ROSENDORFF: Dr Tom Gottlieb is the President of the Australasian Society for Infectious Diseases, which represents about 400 clinicians nationally. Cont/... http://www.abc.net.au/pm/content/2008/s2662248.htm

Doctors scrutinize WHO Swine Flu Vaccine

Some Say While Severe Swine Flu Exists, Warnings May Be Overblown

ABC News

The World Health Organization warned Friday that doctors around the world are now reporting a severe form of swine flu that goes straight to the lungs of otherwise healthy young people -- but some infectious disease experts said the alarm could be unwarranted. Cont/...

.....

But infectious disease experts from both inside and outside the government say that the phrasing used by WHO raises some questions -- particularly because the existence of such a form of the disease is not a new development.

"WHO is certainly putting the fear of [God] in people with this type of release," said William Muraskin, a professor of urban studies at Queens College in New York, who is a specialist in international health. "The description by the WHO is similar to lung infections that claimed so many young people during the 1918 pandemic." http://abcnews.go.com/Health/SwineFluNews/story?id=8438883

Poll

Big Pharma blames CNS symptoms from Lariam, Fluoroquinolones antibiotics or other meds, on either (1) patient suffered from "undetected" psychiatric symptoms prior to the Adverse Reaction (ADR) or (2) that the patient was already taking Anti-Depressants (ADs).

Is it not suspicious that Air Force Pilots or Commercial Airline Line Pilots are advised against taking Lariam??

Compounds in both Lariam and Fluoroquinolones antibiotics are known to act on Gaba receptors, and 5-HTP receptors in the case of Lariam. Notwithstanding the fact, that little is known about neuronal circuitry and its receptors, proteins, neurotransmitters, neurochemicals, and ion channels, prescribing psychotropics will cause more damage.

There are alternatives to psychotropics, safe, effective, and non-addictive!

Be responsible for your health, research, be informed. Those CNS symptoms were chemically induced. Check out the articles about psychotropic drugs published on this blog on 21 July 2009!!

Thank you for doing the poll.

Swine Flu

Moving on from Lariam/Mefloquine and fluoroquinolones,
on to H1N1 (Swine Flu) vaccine and Tamiflu.

From all the research I have done so far, the risks outweighs the benefit, in particular
for us. For those of you still in doubt, read on two of the best articles I could find,
supporting my views. I have yet come across a coherent argument of why those
are necessary, other, than for greed and profit.

The first article give a clear idea of the politics behind the Swine flu, Tamiflu
and vaccines.

I wrote this on FAVC and copied/pasted it here:

Investigation will lead to nowhere, the story will be buried as usual. Bird Flu Accidentally Sent As Vaccine Officials at the World Health Organization and and the European Centre for Disease Control have launched an investigation into how live Avian Bird Flu virus (both H5N1 and H3N2) was accidentally shipped to 18 countries as Bird Flu vaccine. Deerfield, Illinois-based pharmaceutical company Baxter International Inc. accidentally sent an “experimental virus material,” which mixed H3N2 seasonal flu viruses and unlabelled H5N1 viruses, to an Austrian research firm, Avir Green Hills Biotechnology in late December. That company then shipped portions of the mixture to sub-contractors in the Czech Republic, Slovenia and Germany. Subcontractors in the Czech Republic caught the error in early February when testing the shipment on ferrets. The animals died from the inoculation, indicating a live Bird Flu virus. Officials say the 37 people who were exposed to the virus have so far not shown any signs of infection. However, an Austrian news article from February 11 reports a Vienna hospital treated 19 outpatients on February 9 because of exposure to “bird flu virus.” The article said no one was sick, there was no evidence of infection, and the females were prophylaxed with antivirals (presumably Tamiflu). People infected with a mixture of H5N1 and H3N2 viruses could become incubators for a hybrid virus able to transmit easily to and among people. Baxter International Inc. follows a BSL3 (Biosafety Level 3) protocol which prevents the cross-contamination of materials. “It was a combination of just the process itself, (and) technical and human error in this procedure,” said Christopher Bona, Baxter’s director of global bioscience communications. Bona would not give any more information due to “trade secrets”. The mishap comes at an unfortunate time for Baxter International Inc., which was just about to secure a Euopean-wide license for the Avian Bird Flu vaccine. http://tinyurl.com/cpbnmx From The Times mag: http://tinyurl.com/mjxk9d The second article focuses on Tamiflu and its risks, associated with stroke and CNS symptoms: From all the evidence so far, including the Czech Health Officials complaing of it being man made, and no way was it "accidental", it might be conjectural on my part, but it smacks of cover up here...Now, if suspicious Czechs Health Officials had not injected the ferret, with the jab to begin with, this would have gone undetected and caused many deaths. Swine flu may have started in laboratory, expert says 20 May 2009 The man who helped develop the Tamiflu flu anti-viral drug believes the swine flu epidemic has been caused by human error. Adrian Gibbs says the H1N1 virus may have been man-made and was passed to humans after a handling mistake ] at a laboratory. Gibbs, who has studied germ evolution for 40 years, is to publish a paper about his theory, which he developed after studying the swine flu virus’s genetic blueprint. “One of the simplest explanations is that it’s a laboratory escape,” he told reporters from Bloomberg. Viruses are developed on eggs, and Gibbs believes the new H1N1 strain may have accidentally evolved before being passed to humans. He has] discovered that the strain mutates three times faster than the most closely-related viruses found in pigs, which suggests it had evolved outside of swine. It would not be the first time a virus has ‘escaped’ from a laboratory. Earlier this year the avian flu virus made its way into a consignment of ] seasonal flu vaccines, which were destined for around 18 countries in Europe. Some scientists also suspect that the Russian flu outbreak of 1977 was started when a virus was accidentally released from a laboratory. (Source: Bloomberg.com. May 13, 2009). Vaccines infected with deadly avian flu virus 12 March 2009 A large consignment of seasonal flu vaccine, which was due to be circulated to 18 European countries, has been infected with deadly live avian flu virus. ] Had the contamination not been detected, the vaccines may have started an avian flu pandemic, killing hundreds of thousands of people. The World Health Organization is carrying out investigations at the Austrian research facility of Baxter International, the pharmaceutical company, where the contamination happened. Baxter has confirmed that the consignment contained live H5N1 virus, which causes avian flu. A researcher in the Czech Republic discovered the lethal contamination when laboratory ferrets that he had injected with the H3N2 flu vaccine suddenly died. The H5N1 virus becomes lethal as an injection only when it is mixed with H3N2, a process known as reassortment. The WHO investigation team says it doesn’t have evidence to suggest that Baxter had deliberately reassorted the two viruses, but “what remains unanswered are the circumstances surrounding the incident in the Baxter facility,” a WHO official said. Despite dire warnings from health officials, no avian flu pandemic has occurred as human-to-human infection hasn’t happened. So far, several hundred people have died after catching the virus from poultry, although governments have warned that millions would die if people could infect each other. Baxter is currently working on a new type of avian flu vaccine, called Celvapan, which is based on cell culture technology. The technology, which is being developed at Baxter’s research facility in the Czech Republic, by-passes the conventional process where a virus is incubated in chicken eggs. Instead, Baxter is working with the ‘native’ virus that does not need to be modified. Last year the vaccine passed the first two phases of safety trials, and Baxter announced that “Celvapan combines innovative science and breakthrough production technology with the aim of protecting people against an H5N1 pandemic flu infection.” (Sources: Toronto Sun, February 27, 2009; New England Journal of Medicine, 2008; 358: 2573-84).] This article was written by Dr Dr. Anders Bruun Laursen giving an option towards the end of the article, should the vaccine be compulsory! There seems to be quite a lot of uncertainty about the technical nature of Swine Flu (H1N1) vaccines. As a medical doctor, I wish to clarify a number of important issues: First, we should talk about vaccines instead of vaccine, since the vaccines vary as for their compositions and even their ways of being dispensed: some by injection, another by the nose. I think the fears as for the vaccines can be referred to: 1. the adjuvants – in particular squalene which was in all probability responsible for the Gulf War syndrome, 2. the virus antigen´s condition (dead, attenuated, live) 3. a deeply rooted mistrust in our politicians and the vaccine producers´ motives and morals: e.g. Baxter´s live bird flu virus last Winter (12), the Bayer AIDS haemophiliac product scandal (15). First it is necessary to understand, that pandemic vaccines are made according to two procedures: 1. The Developement of a totally new vaccine from scratch. This takes more time, administration and testing than mock up vaccines (see below). 2. A Mock-up vaccine is a vaccine with all the adjuvants of the pandemic vaccine – but without the killed or attenuated pandemic virus. (1) This virus is – until the pandemic virus is known – a different, attenuated known potentially pandemic virus, in the case of the Pandemrix vaccine for the EU it is an attenuated H5N1 bird flu virus. This is the mock-up vaccine. When the nature of the pandemic swine flu virus (H1N1) is known, it replaces the H5N1 virus in an attenuated form, the adjuvants being left unchanged. Until now mock-up vaccine test-vaccinations have been going on on voluntary ”human guinea pigs.” Since most of the contents of the vaccine has already been approved, the approval of the pandemic vaccine is easier to implement. After the exchange of virus in the vaccine, the company will have to apply for a ”variation”. However, this is just a matter of form, since such a variation approval is given by the EU within 5 days – which means that there is no objective testing of the vaccine requiring official approval. The safety is entirely left to the vaccine producer, who has been granted immunity to actions of damages due to expected side effects (2). So, as you see, there is no confusion with regard to swine flu and bird flu viruses. But there is another important consideration: the role of squalene. The average quantity of squalene injected into the US soldiers abroad and at home in the anthrax vaccine during and after the Gulf War was 34.2 micrograms per billion micrograms of water. According to one study, this was the cause othe Gulf War syndrom in 25% of 697.000 US personnel at home and abroad. (3). You can find this table of FDA analyses from the Gulf War lots on The Military Vaccine Resource Directory website (4) a.. AVA 020 - 11 ppb squalene (parts per billion) > b.. AVA 030 - 10 ppb squalene > c.. AVA 038 - 27 ppb squalene > d.. AVA 043 - 40 ppb squalene > e.. AVA 047 - 83 ppb squalene These values were confirmed by Prof. R. F. Garry (5) before the House of Representatives. Prof Garry was the man to discover the connection between the Gulf War syndrome and squalene. According to his findings, the Gulf War syndrome was caused by squalene, which was banned by a Federal Court Judge in 2004 from the Pentagon´s use. (6) As seen on p. 6 of this EMEA document (7), the Pandremix vaccine contains 10,68 mg of squalene per 0,5 ml. This corresponds to 2.136.0000 microgrammes pr. billion microgrammes of water, i.e. one million times more squalene per dose than in (4). There is any reason to believe that this will make people sick to a much higher extent than in 1990/91. This appears murderous to me. I have contacted the Danish National Health Service: They are to decree mass vaccinations in Denmark - and yet they knew nothing about the composition of the Pandremix vaccine. Interesting.. Then I addressed the Danish Medicinal Agency. They admitted that the Pandremix vaccine from GlaxoSmithKline does contain squalene and thimerosal. They have not rejected my remark that the squalene concentration is dangerous. In contrast, the AstraZeneca MedImmune nasal vaccination (8) avoids squalene side effects. So far the use of squalene has been banned by the FDA in the US according to Der Spiegel (9). However, this may not last long (10). "Clearly bypassing the FDA requirements for safety testing of these new adjuvants and the vaccines which contain them puts the entire population at risk for serious, possibly life threatening side effects, particularly any of the 12,000 paid trial participants (6,000 children) who are unfortunate enough to be randomized into the adjuvant containing groups.” Still, on July 23, 2009, the FDA announced, “Currently, no U.S. licensed vaccine contains the adjuvants MF-59 or ASO3 (squalene). It is expected that a novel influenza A (H1N1) vaccine manufactured using the same process as U.S. licensed seasonal inactivated influenza vaccine but administered with MF-59 or ASO3 will be authorized for emergency use only.” Furthermore, “Two of the manufacturers (Novartis and GSK) have proprietary oil-in-water adjuvants (MF-59 and ASO3, respectively) which have been evaluated in a number of clinical studies including studies with influenza vaccines. These manufacturers will include an evaluation of the utility of the adjuvant for dose sparing and higher effect in their clinical studies.“ "The same document indicates that vaccines containing the un-approved adjuvants will be given to 100 children 6 months to 3 years old, 100 children 3 years old to 8 years, 100 individuals 18 to 64 years old and 100 individuals 65 and older in each of the multiple clinical trials. In addition, 700 individuals in each trial will be given non-adjuvanted vaccine". Now for the immunological side effects of squalene to occur takes months to years – and cannot be evaluated after up to 6 weeks of observation. Der Spiegel (9) calls the mass vaccinations on Europeans a gigantic cost free experiment to provide the FDA with mass vaccination experience to clear the track for sale in the US. EMEA admits that side effects can only be found through extensive vaccination campaigns! (1). Here is what EMEA (4) has to say about risks of GSK Pandemrix: EMEAs Pandemrix is commonly or very commonly associated with a range of local and systemic adverse reactions but these are not often of severe intensity and the safety profile would not preclude the use of the vaccine in healthy adults aged 18-60 years or > 60 years. However, there are some adverse reactions known to be very rarely associated with influenza vaccines and it is currently not possible to predict if higher rates might be observed with Pandemrix compared with, for example, seasonal influenza vaccines. Dr Keiji Fukuda, the WHO's flu chief, today warned about the potential dangers of the untested vaccine (11): "There are certain areas where you simply do not try to make any economies. One of the things which cannot be compromised is the safety of vaccines." Which is exactly what is going on! What I do not know is, if they are going to leave the attenuated (or live - Baxter (12)) bird flu vaccine - or to totally replace it by the H1N1 virus. Other severe, but rare side effects are autism in children due to thimerosal (13) and the Guillan-Barré syndrome seen with 400-500 Americans after the 1976 unnecessary mass vaccinations against swine flu (14) – videos. As for additional severe side effects of squalene – see Stephen Lendman (15). [b]My advice: If you are forced to be vaccinated against the harmless swine flu (H1N1) – demand a vaccination with the AstraZeneca nasal vaccine MedImmune (8)– thereby avoiding squalene side effects.[/b] References (1) EMEA http://www.emea.europa.eu/pdfs/human/pan...._46147609en.pdf (2) Global Research 20 July http://tinyurl.com/ljbj3g (3 Wikipedia http://en.wikipedia.org/wiki/Gulf_War_syndrome (4) The Military Vaccine Resource Directory http://www.mvrd.org/showpage.cfm?ID=69 . (5) Statement for Hearing Record, The House Subcommittee on National Security, Veterans Affairs, and International Relations http://tinyurl.com/lzk7gy (6) Wikipedia http://en.wikipedia.org/wiki/Gulf_War_syndrome (7) EMEA http://tinyurl.com/npbvk5 (8) Reuters http://tinyurl.com/kuez7j (9) Der Spiegel http://tinyurl.com/lnmu7c (10) Your Spine http://tinyurl.com/lqx24e (11) The London Evening Standard http://tinyurl.com/mgyvrz (12) The Toronto Sun http://tinyurl.com/9f5v5y (13) Global Research 23 July, 2009 http://tinyurl.com/ox7koq (14) Video 1 http://www.youtube.com/watch?v=IFcnneAqnTM Video 2 http://www.youtube.com/watch?v=-9Bvf9AaC-4 (15) Youtube http://www.youtube.com/watch?v=wg-52mHIjhs (13) Global Research 23 July 2009 http://tinyurl.com/ox7koq (14) 1. video http://www.youtube.com/watch?v=IFcnneAqnTM 2. video http://www.youtube.com/watch?v=-9Bvf9AaC-4 (15) Stephen Lendman, Global Research, 10 June, 2009 http://tinyurl.com/nuswao Surveys can be seen here http://euro-med.dk/?p=9152 and here http://euro-med.dk/?p=9895 The article may be relevant to many of us taking blood thinners in various forms!! Tamiflu puts 600,000 at greater risk of a stroke By Daniel Martin Last updated at 10:47 AM on 19th August 2009 GPs have been put on alert over fears that Tamiflu can put some people at greater risk of suffering a stroke. A Government watchdog is concerned that the anti-swine flu drug can interact with the blood-thinning medication warfarin, which is taken by more than 600,000 people in the UK. The combination can dangerously thin the blood, putting patients at risk of uncontrolled bleeding which can lead to a stroke. The Medicines and Healthcare products Regulatory Agency has already received reports of such cases and has asked health professionals to watch out for more. Last night an expert warned that the dangers have been increased because people given Tamiflu over the national flu hotline are not being warned properly about the possible warfarin risk. The MHRA has now received 418 reports of suspected adverse reactions to Tamiflu, including two deaths. Of these reactions,12 were are due to interactions with warfarin. The number may be small, but the MHRA is sufficiently concerned to place all such reports under 'close review'. It is the latest concern to emerge about Tamiflu, the powerful antiviral handed out by the Government to people with swine flu or flu-like symptoms. Last week, Oxford scientists advised parents not to let children take it because the risks outweighed the benefits. A recent study found Tamiflu caused side effects such as nausea and nightmares in children. On Monday it emerged that ministers ignored a warning from their own advisors that handing out Tamiflu widely could do more harm than good, especially as most swine flu victims suffer only mild symptoms. Health secretary Andy Burnham went ahead with the flu hotline, which lets people get Tamiflu by answering questions from call centre staff who have no medical training. More than 500,000 packs were handed out in the first two weeks. The concern about warfarin centres on the INR rate, which measures how long it takes the blood to clot. The higher the rate, the more the risk of uncontrolled bleeding. Patients on warfarin need regular monitoring to ensure they stay in a safe range. Cont/... http://tinyurl.com/kj2jf Read more: http://tinyurl.com/ms2nog In addition and more importantly, please read this article written by a group of scientists voicing their concerns over the fastracking of the H1N1 vaccine: http://tinyurl.com/m56zqx

Lariam/Mefloquine

If you took Lariam, and suffering from "symptoms" within taking the first tablet, or days, weeks, even up to two years or so, check out this site: http://health.groups.yahoo.com/group/lariam/

Wenn Sie Lariam nahmen, können Sie unter Nebenwirkungen leiden. Schließen Sie sich dieser Gruppe http://health.groups.yahoo.com/group/lariam/ an, um mehr herauszufinden und das Info zu lesen, das auf dem Blog bereitgestellt wird.

Se tiver tomada Lariam/Mefloquine e caído mal cedo após , ou dentro há dois anos enfermo vária sintomas , e visita esse suporte grupo : http://health.groups.yahoo.com/group/lariam/

Nëse keni marrë Lariam / Mefloquine, dhe vuajtur nga simptomat më shpejt pas, apo edhe deri në dy vjet më vonë, lexoni në, dhe vizitoni: http://health.groups.yahoo.com/group/lariam/

إذا كنت استغرق Lariam / Mefloquine ، ويعاني من الأعراض بعد فترة وجيزة ، أو حتى تصل إلى سنتين في وقت لاحق ، على قراءة ، وزيارة الموقع : http://health.groups.yahoo.com/group/lariam

Ако сте направили Lariam / мефлокин, и страда от симптоми скоро след това, или дори до две години по-късно, четете нататък, и посетете: http://health.groups.yahoo.com/group/lariam/

Si vostè va prendre Lariam / mefloquina, i patia de símptomes poc després, o fins i tot fins a dos anys més tard, llegint, i la visita: http://health.groups.yahoo.com/group/lariam/

如果你取甲氟喹/甲氟喹，从症状后不久，甚至长达两年后，阅读的困扰，请访问：http://health.groups.yahoo.com/group/lariam/

如果你取甲氟喹/氟喹和遭受的症狀後不久，甚至長達兩年後，閱讀，並參觀：http://health.groups.yahoo.com/group/lariam/

Ako je Lariam / Mefloquine, a patio od simptoma ubrzo nakon što je, ili čak i do dvije godine kasnije, čitajte dalje, i posjetite: http://health.groups.yahoo.com/group/lariam/

Pokud jste se Lariam / meflochin a trpěl příznaky brzy po, nebo dokonce až o dva roky později, čtěte dál a navštivte: http://health.groups.yahoo.com/group/lariam/

Hvis du tog Lariam / Meflokin, og led af symptomer hurtigt efter, og måske op til to år senere, kan du læse om, og besøg: http://health.groups.yahoo.com/group/lariam/

Als u heeft Lariam / mefloquine, en leed van symptomen kort na, of zelfs tot twee jaar later, lees dan verder en bezoek: http://health.groups.yahoo.com/group/lariam/

Kui te võtsite Lariam / Meflokiin ja kannatanud sümptomid kohe pärast, või isegi kuni kaks aastat hiljem, loe edasi, ja külastage: http://health.groups.yahoo.com/group/lariam/

Kung kayo ay kinuha Lariam / Mefloquine, at nagdusa mula sa mga sintomas sa lalong madaling panahon matapos na, o kahit hanggang dalawang taon mamaya, read on, at bisitahin ang: http://health.groups.yahoo.com/group/lariam/

Jos olet ottanut Lariam / meflokiini, ja kärsi oireista pian sen jälkeen, tai jopa kaksi vuotta myöhemmin, lukemista, ja vierailu: http://health.groups.yahoo.com/group/lariam/

Si vous avez pris Lariam/Mefloquine et avez souffert des symptômes peu après, ou même il y a jusqu'à deux ans plus tard, avez continué à lire et de la visite : http: // health.groups.yahoo.com/group/lariam/

Wenn Sie Lariam/Mefloquine nahmen, und unter Symptomen bald danach, oder sogar bis zu zwei Jahre später litten, lesen Sie auf, und Besuch: http: // health.groups.yahoo.com/group/lariam/

Αν, κατά Lariam / μεφλοκίνη, ενώ υπέφεραν από συμπτώματα αμέσως μετά, ή ακόμα και έως και δύο χρόνια αργότερα, διαβάστε σχετικά, και να επισκεφθείτε: http://health.groups.yahoo.com/group/lariam/

אם לקח lariam / Mefloquine, וסבל תסמינים מיד אחרי, או אפילו עד שנתיים לאחר מכן, קרא ב, ו בקר: http://health.groups.yahoo.com/group/lariam/

यदि आप Lariam / Mefloquine लिया, और लक्षणों से जल्द के बाद, या बाद में भी दो साल के लिए, पर पढ़ने का सामना करना पड़ा, और जाएँ: http://health.groups.yahoo.com/group/lariam/

Ha vett lariam / meflokvin, és szenvedett, a tünetek után nem sokkal, vagy akár két évvel később, olvass tovább, és látogasson el: http://health.groups.yahoo.com/group/lariam/

場合Lariam /メフロキンかかり、症状は直後から、あるいは最大2年後に、読みに見舞われ、訪問：http://health.groups.yahoo.com/group/lariam/

Se si ha Lariam / Meflochina, e soffriva di sintomi, subito dopo, o anche fino a due anni più tardi, a leggere, e visitare il sito: http://health.groups.yahoo.com/group/lariam/

만약 당신이 Lariam / Mefloquine, 데려 증상 직후부터 심지어는 최대 2 년 후, 계속 읽어 고통, 방문 : http://health.groups.yahoo.com/group/lariam/

Ja jūs pārņēma Lariam / meflokvīnu un cieta simptomi drīz pēc tam, vai pat līdz diviem gadiem, lasīt, un apmeklējiet: http://health.groups.yahoo.com/group/lariam/

Jei buvo Lariam / meflokvinu, ir nukentėjo nuo simptomų netrukus po to, ar net iki dvejų metų, vėliau skaityti, ir apsilankymas: http://health.groups.yahoo.com/group/lariam/

Jekk ħadt Lariam / mefloquine, u sofrew minn sintomi malajr wara, jew anke sa sentejn wara, moqri fuq, u żur: http://health.groups.yahoo.com/group/lariam/

Hvis du tok Lariam / Mefloquine, og led av symptomer kort tid etter, eller inntil to år senere, les videre, og besøk: http://health.groups.yahoo.com/group/lariam/

اگر شما در زمان Lariam / Mefloquine ، رنج می برد و از نشانه ها زودتر پس از آن ، و یا حتی تا دو سال بعد ، در خواندن ، و دفعات مشاهده شده : http://health.groups.yahoo.com/group/lariam

Jeśli miała Lariam / mefloquine i cierpiał od objawów wkrótce po lub nawet do dwóch lat później, czytaj dalej, a wizyta: http://health.groups.yahoo.com/group/lariam/

Se você tomou Lariam/Mefloquine, e sofreu de sintomas logo depois, ou até até dois anos depois, leia em, e visita: http: // health.groups.yahoo.com/group/lariam/

Dacă aţi luat Lariam / Mefloquine, şi a suferit de simptome la scurt timp după, sau chiar până la doi ani mai târziu, citiţi mai departe, şi vizitaţi: http://health.groups.yahoo.com/group/lariam/

Если Вы взяли Lariam/Mefloquine, и пострадали от признаков вскоре после, или сглаживать к два года спустя, продолжать читать, и посещения: http: // health.groups.yahoo.com/group/lariam/

Če si vzel Lariam / meflokin, in je utrpela škodo zaradi simptomov kmalu zatem, ali celo do dve leti pozneje, berite dalje, in obiščite: http://health.groups.yahoo.com/group/lariam/

Si usted tomara Lariam/Mefloquine, y sufriera de síntomas pronto después, o hasta hasta dos años más tarde, lea en, y visita: http: // health.groups.yahoo.com/group/lariam/

Om du tog Lariam / meflokin, och led av symtom strax efter, eller ända upp till två år senare, läser vidare och besök: http://health.groups.yahoo.com/group/lariam/

หากคุณเอา Lariam / Mefloquine และรับความเดือดร้อนจากอาการหลังจากหรือแม้กระทั่งถึงสองปีต่อมาอ่านในและไปที่: http://health.groups.yahoo.com/group/lariam/

Eğer lariam / Mefloquine aldı ve belirtiler kısa süre sonra gelen, hatta iki yıl sonra için, okumaya devam yaralanırken, ziyaret edin: http://health.groups.yahoo.com/group/lariam/

Якщо ви взяли Lariam / Мефлохін, і страждав від симптомів, відразу після або навіть до двох років, то читайте далі, і на сайті: http://health.groups.yahoo.com/group/lariam/

High percentage of side effects from Lariam

Not a trip I would recommend, although a little late for some of us. Would it not best to abstain from taking Lariam/Mefloquine? After all, several report taking Lariam and suffering from
Malaria...

Unexpected frequency, duration and spectrum of adverse next term events after therapeutic dose of previous mefloquine next term in healthy adults

Abstract

The frequency and spectrum of previous termadversenext term events associated with the antimalarial therapeutic regimen of previous termmefloquinenext term (MQ) (750 and 500 mg at an interval of 6 h) was assessed in 22 healthy volunteers who were monitored for 21 days following drug administration. An unexpected high frequency of side effects of any grade were reported by all 22 subjects. The most commonly reported symptoms were vertigo (96%), followed by nausea (82%) and headache (73%). Participants suffering from severe (grade 3) vertigo (73%) required bed rest and specific medication for 1 to 4 days. More females than males reported severe previous termadverse reactions.next term The majority (77.3%) of the participants (f: 8/12, m: 9/10) showed symptom resolution within 3 weeks (510 h) after drug administration. Biochemical and haematological findings stayed within the normal range of values, but showed nevertheless a significant rise of Na, Cl, Ca, bilirubin, GGT and LDH. The unexpectedly high frequency and severity of previous termadverse reactionsnext term after normal therapeutic dosage of MQ in healthy subjects may influence future recommendations regarding the use of MQ for stand-by treatment of suspected malaria in travellers.
http://www.sciencedirect.com.proxy.lib.p....38aab3328af18a1

Lariam causes neuronal death

This article clearly show damage causing neuronal death. The author is taking
a cautionary approach, though, implying neurological dysfunction prior to
taking Lariam. We know otherwise.....I suppose, this why I am opposed to
psychotropics. Again, I am not judgemental of those who do, but fear
even more neuronal damage, delaying new neuronal circuitry take place.

Malar J. 2009 Aug 5;8(1):188. [Epub ahead of print]

Epileptogenic potential of mefloquine chemoprophylaxis: a pathogenic hypothesis.

Nevin RL.

ABSTRACT: BACKGROUND: Mefloquine has historically been considered safe and well-tolerated for long-term malaria chemoprophylaxis, but prescribing it requires careful attention in order to rule out contraindications to its use. Contraindications include a history of certain neurological conditions that might increase the risk of seizure and other adverse events. The precise pathophysiological mechanism by which mefloquine might predispose those with such a history to seizure remains unclear. PRESENTATION OF THE HYPOTHESIS: Studies have demonstrated that mefloquine at doses consistent with chemoprophylaxis accumulates at high levels in brain tissue, which results in altered neuronal calcium homeostasis, altered gap-junction functioning, and contributes to neuronal cell death. This paper reviews the scientific evidence associating mefloquine with alterations in neuronal function, and it suggests the novel hypothesis that among those with the prevalent EPM1 mutation, inherited and mefloquine-induced impairments in neuronal physiologic safeguards might increase risk of GABAergic seizure during mefloquine chemoprophylaxis. Testing and implications of the hypothesis Consistent with case reports of tonic-clonic seizures occurring during mefloquine chemoprophylaxis among those with family histories of epilepsy, it is proposed here that a new contraindication to mefloquine use be recognized for people with EPM1 mutation and for those with a personal history of myoclonus or ataxia, or a family history of degenerative neurologic disorder consistent with EPM1. Recommendations and directions for future research are presented. http://tinyurl.com/lcrgwh

Lariam side effects

Through legistlation in 2002, Roche included side effects and adverse reactions to Lariam/Mefloquine for patients inserts. The Department of Veterans also published a list of side effects causing long term damage. This includes, cardiovascular, gastrointestinal, endocrinological, cognitive, neuropsychiatric, sensory system, haematological, kidneys, liver, skin, neurological, mitochondria, ions channels, showing how toxic this chemoprophylaxis can be! Connecting the dots with ChemoProphylaxis??

Note that on all inserts in packaging, side effects are described as "Rare" or "Infrequent" does not reflect some published articles, or what is being reported. More on FDA's and MRHA's reporting system later.

Unfortunately, many symptoms are delayed and can manifest themselves sometimes two or more years after taking it.

Furthermore, taking one pill only, can and do cause listed above damage to many. Medical Doctors are very reluctant to give a diagnosis of Lariam toxicity, making it very difficult for patients to access care, except for psychotropics, if suffering from neuropsychiatric symptoms. These drugs are not helpful long term, are addictive and cause more damage to neuronal circuitry. Overall, Medical Doctors, rarely, if ever, diagnose prescribed drug Adverse Reactions. They are dismissive of correlation of symptoms and side effects!!

Factors involved in side effects and adverse reactions are poorly understood. Extraneous variables include what was eaten on that day, alcohol consumption, the temperature, gender, ethnicity, weight, CPYs in the liver, digestive system, kidneys, detoxification Phase I & Phase II, genetic polymorphisms, and pharmacodynamics/pharmacokinetics of Lariam. In no way, does this mean that there is a genetic malfunction, rather, that Lariam is a very toxic drug, and those who do not react are very lucky. This could be due to the fact that during that period of time, they were able to avoid Lariam reaching toxic level by excreting it more efficiently. It is worth noting that most drugs are only effective for less than 10% fo the general population.

It is not feasible to manufacure any pharmaceutical drugs to suit everybody's unique biochemistry.

Published research focuses on neuropsychiatric and neurological side effects, in particular suicides, but lacking in other long term side effects such as cardiovascular, which can be devastating.

For those of you suffering from side effects from Lariam, please read:

http://tiny.cc/2rKP9
http://tiny.cc/oPnlZ
http://www.lariam.dk/Trial.htm

I have an old pdf format of a document concerning long terms effects of Lariam from the Department of Veterans Affairs, which was not found on their site today. Has it been deleted? Those who wish to have a copy, please register, leave a comment with your email address, requesitng your email address to be deleted before publishing your comments.

For those of you suffering neuropsychiatric symptoms, there is hope. These symptoms will fade in time, specially for those who are able to resist the lure of psychotropics. Do not allow psychiatrists convince you that you had an underlying psychiatric condition which suddenly appeared after taking Lariam. Or that you are personality Type A, driven and ambitious, thriving on stress, etc. Lariam does NOT work that way.

Some medications, in particular Lariam and Fluoroquinolones are known to cause chaos in neuronal circuitry. Moreover, there is little knowledge concerning neuronal circuitry, but sufficient data and research show serious damage to the central nervous system, can and do occur by certain types of medications.

The next post will focus on Lariam pharmacodynamics and pharmacokinetics.

Information and published papers concerning Lariam/Mefloquine were NOT copied from any other Lariam sites, but researched from the orignial source.

Mefloquine - antagonists of 5-HT3

This one of the reasons, I am opposed to anti-depressants. Although, this paper was published in 2007, it is still very relevant!!

The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT3 receptors
A J Thompson,1 M Lochner,1 and S C R Lummis1*
1Department of Biochemistry, University of Cambridge, Cambridge, UK
*Author for correspondence:
Received November 1, 2006; Revised January 3, 2007; Accepted January 5, 2007.

Abstract
Background and Purpose:
The antimalarial compounds quinine, chloroquine and mefloquine affect the electrophysiological properties of Cys-loop receptors and have structural similarities to 5-HT3 receptor antagonists. They may therefore act at 5-HT3 receptors.

Experimental Approach:
The effects of quinine, chloroquine and mefloquine on electrophysiological and ligand binding properties of 5-HT3A receptors expressed in HEK 293 cells and Xenopus oocytes were examined. The compounds were also docked into models of the binding site.

Key Results:
5-HT3 responses were blocked with IC 50 values of 13.4 μM, 11.8 μM and 9.36 μM for quinine, chloroquine and mefloquine. Schild plots indicated quinine and chloroquine behaved competitively with pA 2 values of 4.92 (K B=12.0 μM) and 4.97 (K B=16.4 μM). Mefloquine displayed weakly voltage-dependent, non-competitive inhibition consistent with channel block. On and off rates for quinine and chloroquine indicated a simple bimolecular reaction scheme.

Quinine, chloroquine and mefloquine displaced [3H]granisetron with K i values of 15.0, 24.2 and 35.7 μ M. Docking of quinine into a homology model of the 5-HT3 receptor binding site located the tertiary ammonium between W183 and Y234, and the quinoline ring towards the membrane, stabilised by a hydrogen bond with E129. For chloroquine, the quinoline ring was positioned between W183 and Y234 and the tertiary ammonium stabilised by interactions with F226.

Conclusions and Implications:
This study shows that quinine and chloroquine competitively inhibit 5-HT3 receptors, while mefloquine inhibits predominantly non-competitively. Both quinine and chloroquine can be docked into a receptor binding site model, consistent with their structural homology to 5-HT3 receptor antagonists.

Keywords: 5-HT3 receptor, Cys-loop receptor, binding site, ligand docking, malaria, quinine, chloroquine, mefloquine, antagonist.....

Conclusion

Cont/.....

In summary, we have used a combination of electrophysiology, ligand binding, homology modelling and simulated docking to define the mechanisms by which quinine, chloroquine and mefloquine inhibit the 5-HT3 receptor response. Our observations further extend the number of receptors known to be affected by these compounds and the growing diversity of targets may account for the broad spectrum of side effects that have been reported by patients receiving them (Luzzi and Peto, 1993; Palmer et al., 1993; Taylor and White, 2004). Inhibition of the 5-HT3-mediated current could have wide-ranging effects in the nervous system, as 5-HT3 receptors can modulate a variety of neurotransmitter responses such as those to GABA, dopamine and cholecystokinin (Thompson et al., 2006b).http://tinyurl.com/ny2zqv

Serious Side Effects of Anti-Depressants

A few more videos and one more article, after which, a break from writing about Anti-Depressants.

There is a strong movement of psychiatrists who are opposed to promoting psychotropics. They are campaigning for a paradigm shift in psychiatry. Neuroscientists are coming closer to showing "mental illnesses" are biological. It is known for a long time that CNS can be triggered by ADRs from prescribed medications, trauma injury to the head, stroke, hypothyroidism, infectious pathogens, mycotoxins, heavy metals, hormonal imbalance and more. We know very little, about neuronal circuitry. At this time, it is conjectural to imply for any drugs to improve brain function, alleviate depression, cure or improve psychiatric symptoms. The science does not support such claims. What is taught at Universities in text books of Psychology, Psychiatry and Neuroscience, is not supported by claims made by Pharmaceutical companies.

Thomas Szasz, http://www.szasz.com/a famous psychiatrist, Nobel Prize winner and Professor Healy, Professor Ashton, Dr David Permlutter and other famous psychiatrists, and neuroscientists, have written important articles and books on this matter.

If staying away from benzos and anti-depressants, these symptoms will resolve, in time.

Incidentally, most prescriptions for Klono is 0.2 mg and 0.5 mg, and very difficult to stop, for many, even after one week of starting. The options are to up the dosage or start tapering, under supervision of a medical professional.

Klonopin carries with an insert warning that it should not be taken longer than a few weeks, yet, it is highly addictive, from the first pill.

Why are doctors renewing prescriptions when manufacturers are saying themselves, it is highly addictive and should not be taken for more than a few weeks.

Again, it is about profit. The pharmaceutical industry make a yearly profit of approximately $40 billion a year!! Why should we bump up their shares whilst making ourselves ill and poorer??

Who suffers? The patient...

For those of you taking Benzos, such as Klonopin, suffering from symptoms as described below, please seek help.

Lastly, many of us suffered all the torturous symptoms as listed below from floxing and from Lariam or other meds, we recovered by abstaining from taking anti-depressants and psychotropics.

It is very important to seek help if displaying these symptoms whilst on Klono. The consequences can be very serious, both mentally and physically.

Below is a list of symptoms as reported by those who are taking Benzos and other psychotropics. Those drugs prolong CNS symptoms, and could trigger life threatening side effects. For thos who wish to switch, taper or wean, in your own time, when you are ready, (under supervision of your doctor), see this excellent guide written by world renowned psychiatrist, Professor Heather Ashton http://lonelylinks.com/download/Chapter1.pdf

An E- Support group organizing conferences, chaired by MDs, Psychiatrists etc. www.april.org.uk

Visual perceptual

Derealisation, Depersonalisation, Distortion of body image, Feeling like legs and arms are not attached to body
Psychotic symptoms


Auditory hallucinations, Catatonic episodes, Compulsive suicidal ideation, Confusion, Delusional thinking, Disorientation, Formication (sensation that I had fleas/spiders crawling over me)



Mood

Aggression, Anger, Agoraphobia, Agitation, Akathisia, Anxiety, Apathy, Anhedonia (inability to experience pleasure), Crying and feeling weepy, Deep depression, Despair, Dysphoria, Extreme dispassion, Fear, Fear of dying, Fear of losing control and going insane, Fearing symptoms are not withdrawal, Fearing that you will never get better, Fear of life, Fear that symptoms are permanent, Feeling emotional, Feeling frightened, Feeling hopeless, Feeling like jumping out of skin, Feeling that the world is about to cave in on you, Frustration, Gittery, Gloom and doom, Inability to appreciate humour and laugh, Inability to feel emotions, Inability to feel joy, Inability to feel pleasure, Internal feeling of anxiety with no corresponding external cause, Irrational fears, Irrational rage, Irritability, Lonliness, Low mood, Nervousness, No feelings of fun or laughter, Obsessive thoughts, Overwhelmed feeling, Rapid mood fluctuations, Sensitive feelings, Severe negative looping thoughts, Sudden sadness, Terror, Void of normal emotions



Mental status

Difficulty in distracting oneself, Feeling disconnected, Feeling drugged, Feeling freaked out, Feeling like a zombie, Feeling like being on a bad LSD acid trip, Feeling numb, Feeling scared, Feeling that you're just going crazy, Feeling traumatised, Feeling unreal, Getting worried over small things, Hallucinations, Horrid visions, Hypomania, Images and songs keep repeating in mind, Inability to relax or sit still, Intrusive thoughts, Jumpiness, Loss of sense of identity, Misperceptions, Morbid thoughts, Morning madness, Not knowing who you are, Obsessive and compulsive thinking (OCD), Overwhelming feeling that you are going to die, Pacing, Panic attacks, Paranoia, Racing thoughts, Reduced stress tolerance, Suicide attempts, Suicidal thoughts, Thinking you are mentally ill, Unwarranted feelings of guilt, Visual hallucinations, Vivid dreams, Weird thinking, Wired feeling


Eyes and ears

Bloodshot eyes, Blurry vision, Dark-dim vision upon exertion or sunlight, Difficulty seeing, Drooped eyelids, Dry eyes, Eye twitching, Flashes of light in the eyes, Fuzzy eyes, Glassy eyes, Impaired vision, Occasional right eye pain, Pressure in the inner ear and outer ear, Red burning eyes, Sore eyes, Swollen eyes, Tearing eyes, Uncontrolled eye movement, Visual distortions preceding a migraine


Behavioural

Constant need to be occupied, Avoiding friends and people, Inability to occupy oneself


Visual perceptual

Derealisation, Depersonalisation, Distortion of body image, Feeling like legs and arms are not attached to body
Psychotic symptoms
Auditory hallucinations, Catatonic episodes, Compulsive suicidal ideation, Confusion, Delusional thinking, Disorientation, Formication (sensation that I had fleas/spiders crawling over me)


Cardiovascular

Chest pains, Fast heartbeat, Heart palpitations, Heart pounding, Low blood pressure, Premature ventricular contractions (irregular heart beats), Pulsating all over my body(also visable), Pulse thudding, Racing heart, Severe pain chest, Skipping heart beats, Tightness in chest


Cognitive symptoms

Can't do tasks like make food, Difficulty reading, Difficulty thinking, Forgetting names of family members, Hard time with words, Impaired cognitive skills, Impaired communication skills, Inability to focus, Inability to function, Inability to learn, Jumbled thoughts, Lack of concentration, Memory and comprehension problems, Poor judgement, Poor memory, Short-term memory problems, Slow thinking processes, Spaciness


Muscular

All muscles moving, All muscle tone feels flacid, Body feels twisted, Cranial tightness (felt my head was decompressing), Difficulty walking due to weakness and shaking, Face spasms, Inner tension, Inner vibrations, Jaw clenching (can't open or close mouth properly due to the spasms and pain), Jaw Spasms, Legs and arms shake, Muscle twitching, Muscle spasms, Rigidness and jerks, Muscle aches, Muscle cramping, Muscle tension, Muscle wasting, Muscle weakness (especially in the legs, arms and hands), Jelly legs, Restless legs, Stiff arms and legs, Stiff muscles, Stiffness in back, Teeth chattering, Tension in neck, Tight achy muscles, Tight jaw and temple, Tight head, Tight muscles in left leg, Tight muscles in neck and shoulders, Trembling and shaking, Tremors, Weakness, "jelly legs"

Nerves

All nerves firing off, Ankles reflexes diminished
Eyes and vision
Eye fluttering and twitching, Eye pain, Pain in eyes
Bone
Skeletal aches
Joints
Joint pain
Urinary
Difficulty urinating

Gastrointestinal

Bloating, Constipation, Choking, Diarrhea, Dry heaving, Fast and fine vibrations of the stomach, Gas, Knot in stomach, Loss of appetite and weight loss, Malabsorption, Nausea and vomiting, Severe pain in stomach, Slow heart rate, Swelling-bloating, Tachycardia, Weight gain


Mouth

Acid reflux, Dental pain (tooth pain), Dry mouth, Sore tongue, Metallic taste, Sore gums, Sore mouth, Too much saliva

Pain

Abdominal pain, Aching pain in legs, Bladder ache, Body aches, Headaches, Jaw pain, Lower back pain, Muscle and joint pain, Nail Pain, Neck pain, Nerve pain (hitting non-specific areas of the body randomly, but for short bursts), Pain in hands and feet, Pain in previous surgical sites, Severe bone pain, Severe head pain, Sore tongue and throat, Stinging pain, Teeth pain (felt like I had braces on), Throbbing pains, Throbbing legs, Waves of pain

Respiratory

Breathlessness, Chest discomfort and tightness, Difficulty breathing, Hyperventilation (overbreathing), Shallow breathing


Sensitivity

Chemical sensitivity, Cold extremities, Creepy crawlies on hands and arms, Feel cold even in hot weather, Food sensitivity, Intolerance to cold and heat, Intolerance to music, Photosensitivity, Sensitive to music, Sensitive to loud noises, Sensitive to light and stress, Sensitivity to smells, Very cold especially hands and feet


Sensorary

Brain nerve pain, Burning feet and legs, Buzzing throughout body, Chills, "Electric shock" sensations, Electric static shooting around body, Food doesn't have much taste, Head sensations, Heavy sensation in forehead and eyes, Heightened sense of smell, Hypersensitivity to light, Hypersensitivity to odors, Hypersensitivity to sound, Hypersensitivity to stimuli, Intense burning head/brain, Intense burning scalp, Intense burning spine, Itchy head and face, Numbness and tingling in face, Numbness and tingling in feet, Numbness and tingling in hands, Numb area on bottom of left foot, Numbness in arms, Numbness in face and left side, Numbness in fingers, Numbness in head, Numb right foot, Numbness in lip and tongue, Pins and needles, Sensory disruption, Soapy taste in mouth, Stabbing pains in limbs, Tingling on scalp, Tinnitus


Skin

Burning patches, Chapped skin, Cold sweats, Dermatographism, Dry itchy skin, Eyebrow loss, Feeling hot, Hair loss, Hives, Itching and stinging from head to toe, Itching sensation under my skin, Lashes falling out, Night sweats, Rashes, Rash under brows, Skin sensitivity, Sweating, Tingling skin, Very oily skin and hair


Sleep

Anxiety dreams, Frequent awakenings during the night, Horrific nightmares, Hypnagogic hallucinations, Jolts that wake you up, Lack of deep sleep, Poor sleep, Rebound REM sleep, Severe insomnia and tiredness, Sleep paralysis, Twilight sleep, Waking early, Weird dreams


CNS

Adrenaline jolts, Brain fog, Dizzy, Frozen feeling (like I need to get up and do something but can't do the action), Hypervigilence about symptoms, Impaired vigilance, Increased nicotine craving, Lack of energy, Lack of motivation, Light-headedness (especially when I stand too quickly), Loss of balance, Loss of sex drive, Mental and physical exhaustion, Migraine headaches, Pounding in my head, Pressure in head, Pulsating in right temporal area especially upon exertion, Restlessness, Room spinning, Seizures, Severe fatigue, Thirst, Vertigo, Voice weak


Immune system

Fevers, New allergies, Ulcers in mouth, Worsening of allergies


Female

Irregular Menstrual Cycle


Body

Feeling as if been punched in gut and chest, Feeling heavy legged, Feeling unwell, Flu like symptoms, General malaise, Going from hot and sweaty to cold and clammy, Hot and cold flushing, Increased number and severity of infections, Severe body pain, Water Retention


1. ACUTE:

- aggression
- anxiety
- agoraphobia
- apathy
- ataxia
- breathlessness
- chest discomfort and tightness
- choking
- constipation
- convulsions (muscle usually)
- dental pain
- depersonalisation
- depression
- derealisation
- diarrhoea
- distortion of body image, misperceptions
- dry, itchy skin
- "electric shock" feelings throughout the body
- dysphoria
- excitability
- fasciculations
- flushing
- formications
- head sensations
- heart palpitations
- hyperacusis
- hypersensitivity to stimuli
- hyperosmia (sensitive sense of smell)
- hyperpyrexia (overheating)
- hyperventilation (overbreathing)
- insomnia
- intrusive thoughts
- irrational rage
- irritability
- jumpiness
- metallic taste
- nausea
- nightmares
- obsessions
- panic attacks
- perceptual disturbances and distortions
- photosensitivity
- psychotic symptoms (usually transient and
confined to rapid withdrawal)
- restlessness
- seizures (on abrupt discontinuation)
- sensory disruption
- scalp burning
- sore tongue
- sweating, night sweats
- tinnitus
- tremor
- vomiting
- weakness, "jelly legs"
- weight gain
- weight loss (this may be quite rapid)

Cold Turkey

Symptoms usually confined to 'cold turkey' or rapid
withdrawal from high doses of benzodiazepines:
- confusion
- delirium
- fits
- hallucinations
- psychotic symptoms
- seizures

2. PROTRACTED:

- abnormal muscle tone
- anxiety
- aching joints
- ataxia
- allergic reactions
- back pain
- blepharospasm (eye twitching)
- breast pain
- apathy
- constipation (often alternating with diarrhoea)
- cravings
- dehydration
- dental pain
- depersonalisation
- depression
- derealisation
- diarrhoea (often alternating with constipation)
- dry, tickly cough
- dysphagia
- fluctuations in blood pressure
- "electric shock" feelings throughout the body
- fasciculations
- formication (sensation of bugs crawling over skin)
- gait disturbance (the ground seems to move underfoot)
- gastritis
- glassy eyes
- hair loss
- heartburn
- heart palpitations
- heavy flu-like symptoms
- hyperacusis
- hyperaesthesia (sensitivity to stimuli)
- hyperosmia
- insomnia
- iris colour changes
- kakosmia
- joint pains
- leukonychea (whitening of nails)
- libidinal changes
- malabsorption
- menstrual irregularity
- muscular cramps
- muscular rigidity
- muscular spasms
- muscular (and bone) weakness
- myoclonic convulsions (muscle/nerve spasms)
- nausea
- neurological problems (topical nerve anaesthesia)
- nose bleeds
- oedema (especially of ankles and face)
- oesophagitis
- paraesthesiae (numbing, burning and tingling; pins and needles)
- poor concentration
- poor short-term memory
- perspiring, night sweats
- severe headaches
- sinusitis
- skin insensitivity
- sore, itchy eyes
- spine (burning sensation)
- stomach cramps
- thirst
- thrush-like symptoms
- tremor
- tinnitus (ear buzzing, popping, ringing, hissing)
- tiny pupils
- urinary problems (bladder either 'all on' or 'all off')
- vertigo
- visual disturbances (blurred, double, vivid)
- vomiting
- water retention

3. PARADOXICAL:

- acute hyperexcited state
- agitation
- aggressive behaviour
- anxiety
- breathlessness
- excitability
- fear
- hallucinations
- hostility
- hyperactivity
- increased muscle spasticity
- irrational rage
- insomnia
- nervousness
- nightmares, vivid dreams
- phobias
- rage
- restlessness
- restless legs, arms
- sleep disturbances
- tension
- tremor
- panic attacks

4. TOLERANCE EFFECTS (including toxicity):

- anxiety
- apnea (night)
- breathlessness
- dyspnea (breathing problems)
- fibrositis
- fatigue
- gait disturbance
- impotence
- leaden heaviness
- lethargy
- libido disturbances
- loss of self-confidence
- menstrual irregularity
- neurological problems
- panic attacks
- phobias
- severe muscle rigidity
- short-term memory impairment
- vasovagal attacks
- vertigo

5. SIDE EFFECTS:

- abnormal behaviour or false beliefs
- aches and pains (muscle tension)
- aggressiveness
- agitation
- agoraphobia and claustrophobia
- anger
- anti-social behaviour
- apathy
- ataxia
- blood disorders (resulting in severe tiredness
and possible infections)
- blurred vision
- bradycardia (slow heartbeat/pulse)
- breast enlargement
- changes in appetite
- changes in libido
- changes in salivation
- chemical sensitivities, allergies
- cognitive impairment
- confusion
- daytime drowsiness
- depression
- diarrhoea and constipation
- diplopia
- dizziness
- dry, itchy skin
- dysarthria
- dysphoria
- emotional blunting
- exhaustion
- fatigue
- feeling afraid
- feeling unreal
- feelings of anger and anxiety
- flu-like symptoms
- hair loss
- hallucinations
- headaches
- hypotension
- IBS (Irritable Bowel Syndrome)
- inability to pass urine/holding of urine in the bladder
- impairment of motor co-ordination
- incontinence
- insomnia
- irritability
- jaundice
- jaw pains
- lack of concentration
- lack of confidence
- lethargy
- many people wonder why they have changed from being happy
and outgoing, to being over-anxious and unconfident
- memory loss or forgetfulness
- mild hypertension
- muscle weakness, spasticity, cramps, abnormal tone
- nausea
- nightmares
- numbed emotions
- oedema
- panic attacks
- personality changes
- poor muscle control
- problems with vision
- psychomotor impairment
- rashes
- reduced alertness
- reduced blood pressure
- restlessness
- shivering
- skin problems, rashes
- sleep problems
- slurred speech
- stomach and bowel problems
- stomach upsets
- suicidal behaviour
- thyroid disturbances
- tolerance
- tremor
- urinary retention
- vertigo
- violence
- water retention
- weight gain
- xeroderma (dry skin)

6. CATEGORIES OF SYMPTOMS:

CARDIOVASCULAR:

Fluctuations in blood pressure
Mild hypertension
Shivering, feelings of extreme cold or hot
Heart palpitations

DERMATOLOGICAL:

Allergic reactions
Chemical sensitivities
Dry, itchy skin
Dry throat, sore tongue, and thrush
Formications (sensation of crawling on skin)
Glassy eyes
Hair loss
Leukonychea (whitening of nails)
Nosebleeds
Oedema
Paraesthesiae (numbness, tingling)
Perspiring, night sweats
Rashes, blotches

GASTROINTESTINAL:

Bladder incontinence
Constipation (sometimes alternating with diarrhoea)
Diarrhoea
Dyspepsia (indigestion)
Gastritis
Heartburn
Nausea
Oesophagitis
Stomach cramps

GENITOURINARY:

Impotence
Libido disturbances
Menstrual irregularities
urinary problems (continence or incontinence)
Encopressia (faecal incontinence)

MUSCULOSKELETAL:

Aching joints
Blepharospasm (eye twitches)
Formication (sensations of bugs crawling on skin)
Gait disturbance
Jaw, tooth, neck and shoulder pain
Muscle wasting
Muscle spasms
Rapid weight loss
Severe headaches
Severe muscle rigidity
Tremor or feeling of inner vibration
Vertigo

NEUROLOGICAL:

Blurred vision, seeing spots, flashes, vivid vision
Bruxism (teeth grinding)
Dysphagia (difficulty eating or swallowing)
Electric shock feelings
Fatigue, leaden heaviness
Hypersensitivity to light, sound, and other stimuli
Neurological problems (e.g. topical anaesthesia)
Severe muscle rigidity
Speech difficulty
Thirst
Tinnitus (ear buzzing, popping, ringing, hissing)
Tiny pupils
Tremor

PARADOXICAL:

Agitation
Aggressive behaviour anxiety
Breathlessness
Excitability
Fear
Hostility
Hyperactivity
Irrational rage
Insomnia
Nervousness
Nightmares, vivid dreams
Phobias
Restlessness

PSYCHIATRIC:

Apathy
Anxiety
Delirium
Depersonalisation
Depression
Derealisation
Distortions or hallucinations
Dysphoria (inability to feel pleasure or happiness)
Fear
Hyperventilation
Hyperreflexia (‘jumpiness’)
Hypnologic hallucinations sleepwalking)
Lack of concentration
Nightmares
Obsessions
Paranoia
Phobias (hydrophobia, agoraphobia, monophobia,
acrophobia, anthropophobia and others)
Rapid mood changes
Suicidal thoughts
Short-term memory impairment

RESPIRATORY:

Breathlessness
Choking
Dry, tickly cough
Dyspnea (breathing difficulty)
Hyperventilation (overbreathing)
Inability to draw satisfying breath
Night apnea
Sinusitis

http://benzowithdrawal.com/forum/index.php exellent forum

http://www.non-benzodiazepines.org.uk/

http://www.benzo.org.uk/ (excellent site)

there are other helpful sites

On a lighter note,

Previous | Start | Next

Books re: psychotropics

For those who started on Psychiatric drugs, but wish to wean and taper, books such "Brain Book" by Dr David Permlutter, Neuroscientist and "Coming off psychiatric Drugs, by Peter Lehmann, Judi Chamberlin, Pirkko Lahti, and Loren R. Mosher are helpful.

Professor Ashton's Manual concerning Benzodiazepines, on how to switch to Diazepam, and taper and wean is a must read. The Manual emphasizes safety. http://www.benzo.org.uk/manual/bzsched.htm

There are many books, written by psychiatrists and Neuroscientists, concerning psychotropics, avoidance, alternatives, withdrawal, tapering and weaning safely.

Caution: weaning and tapering should be under the supervision of your psychiatrist.

Medicines & Diseases causing psychiaric symptoms

A number of meds and indeed diseases, can induce sudden or delayed, neuropsychiatric symptoms. Fluoroquinolones antibiotics, Lariam/Mefloquine, beta blockers, Anti depressants, analgesics, anesthetics (both general and local) and many more.

Conditions such as hypothyroidism, Huntington's Disease, Lyme Disease, infectious pathogens, mercury and other heavy metals accumulation, changes in hormones, etc.. are also known to cause neuropsychiatric symptoms.

Below is an article, alerting about asthma drug suspected of causing neuropsychiatric symptoms in children. I suspect this is also happening to adults. Nasacort for sinusitis and rhinitis, can also cause neuropsychiatric symptoms.

If your or a member or family suddenly or over a period of time, display psychiatric symptoms, please, investigate.

Often, there is an underlying cause as mentioned above. Avoid psychiatric drugs, see vids posted below.

Asthma Drug linked to suicide attempts, thoughts of self-harm

By Bradley Bouzane, Canwest News ServiceJuly 7, 2009

OTTAWA — The side-effects of a popular asthma medication that has been sold in Canada for 12 years has been linked to suicide attempts and thoughts of suicide, as well as feelings of depression and hostility.

The July 2009 issue of the Canadian Adverse Reaction Newsletter from Health Canada cites montelukast sodium — which has been marketed in Canada since 1997 as Singulair — as having several connections to the alarming reactions.

Between its introduction to the Canadian market and Jan. 31, 2009, Singulair has been linked to two suicide attempts in Canada and 11 cases where users had thoughts of suicide or self-harm. In 29 other cases, 14 of which were labelled as "serious adverse reactions," those affected suffered from depression, hostility or other psychosis. No deaths have been linked to the drug's side-effects.

Karen Liberman, executive director of the Mood Disorders Association of Ontario, said the side-effects are disturbing, given how common asthma is.

"It's kind of like a perfect storm," Liberman said. "Asthma is so prevalent, and depression and bipolar (disorder) and anxiety are more prevalent.

"One of the things we know about these illnesses is they are susceptible to stress on the body, whether it's chronic pain, life stress or relationship stress. If you carry the genetic vulnerability to depression, these are the things that can trigger it. As you can imagine, if you are someone with a chronic disease like asthma, and you take medication that's supposed to help, and it precipitates something like depression, that would be very troubling."

Between September 2007 and July 2008, the list of adverse reactions stemming from the drug was amended in Canada, which warns patients that "if suicidal thoughts and actions occur, montelukast should be discontinued and a physician or pharmacist contacted immediately."

In eight reported cases, thoughts of suicide or self-harm subsided once the dose was reduced or stopped completely, while the same adverse reaction returned in one case when the dose was restarted.

In the 29 less severe cases, the reactions were eliminated by lowering the dose or stopping use of the drug in 19 of those cases. Upon reintroduction, the symptoms returned in four cases.

More than half of the reported cases — 26 of 42 — were in people under the age of 18.

The drug is used to treat asthma in people older than age two, as well as patients age 15 and older who suffer from severe seasonal allergies. Cont...http://www.leaderpost.com/news/Asthma+drug+linked+suicide+attempts+thoughts+self+harm/1768232/story.html

Popular Asthma Medicine Singulair Associated With Psychiatric Disorders In Children

New Medical Journal Article Follows June 2009 FDA-Required Warning For Singulair About Neuropsychiatric Events

(Posted by Tom Lamb at DrugInjuryWatch.com)

On June 12, 2009 the FDA announced a new warning about an increased risk of neuropsychiatric events for the asthma medicine Singulair (montelukast)-- as well as some other less popular leukotriene inhibitors, Accolate (zafirlukast) as well as Zyflo and Zyflo CR (zileuton).

http://www.drug-injury.com/druginjurycom/drug_safety_alerts/

Blog content & Vids re: Benzos withdrawal

This blog is about recovering from Adverse Drug \Reactions/Side Effects, (inc vaccines). Published articles concerning pharmacodynamics and pharmacokinetics, damage to mitochondria & methylation (caused by medicines), epigenetics, phytochemistry, Ayurvedic medicine, and other validated alternatives therapies such as Orthomolecular medicine, (vitamins and supplements) referenced from various scientific medical/ journals.

Topical comments pertaining to this blog are welcome.

For those of you suffering from an Adverse Reaction/Side Effects, there is hope. There are vitamins and supplements which are very helpful to help detoxing, such as magnesium orotate, magnesium citrate for palpitations, Vitamin E, Fish Oil containg EPA/DHA, ALA, NAC etc.. I will write an article concerning these.

If you are suffering from neuropsychiatric symptoms(CNS) as side effects, avoid psychotropics.

They are extremely addictive, may cause more damage, and are not a cure, not even temporary. Benzodiazepines (Benzos) are extremly addictive, and very difficult to wean off for most. Look up Benzodiazepines Withdrawal on You Tube before taking one!! There are alternative neuroscientists and psychiatrists using vitamins and supplements, herbs and NeuroFeedback. Most neuropsychiatric symptoms subside, with time. For some, it may take a few weeks, others a few years.

I will write more about CNS symptoms and various safe coping strategies. Meanwhile, look up "Altering Brain Chemistry" on http://noquinolones.proboards.com/index.cgi?board=treat&action=display&thread=1192 Listed are some remedies, validated with scientific research such as Ashwaganda, Bacopa and Heel's homeopathic remedies, and more.

Avoid Neurotonin, Cymbalta and other benzos type of pain killers. They belong to the same class of drugs as Benzos attaching themselves to Benzos receptors, causing even more long term damage. Often, those suffering from an ADR causing neuropathic pains, nerve fibers will heal in time. If taking strong listed analgesics, these nerve fibers may suffer more damage, delaying recovery, and may not heal.

Vids concerning Benzos withdrawal:

Warnings about Fluoroquinolones antibiotics:

New Vids by MrFloxed

Regardez bien le vid sur les fluoroquinolones antibioques!!
Avant d'en prendre, renseignez vous.
Effets secondaires, n'attendez pas,
regardez ce site et les vids sur le "Video Bar"

http://quinolones.free.fr/AVQ/projets.html
www.favc.info

Bevor Sie fluoroquinolones Antibiotika nehmen, informieren Sie sich über Risiken.
Wenn Sie die Antibiotika nehmen, die unter Nebenwirkungen leiden, betrachten Sie jene "Videos Bar" und Sites: www.favc.info

Se lei porta un antibiotico di fluoroquinolone e sospetta una reazione avversa, uno sguardo su quei video sulla "Video Bar" e questo luogo: www.favc.info

Si usted toma un antibiótico de fluoroquinolone y sospecha una reacción adversa, la mirada arriba esos vídeos "Video Bar" en la barra vídeo, y en este sitio: www.favc.info

Om du tar en fluoroquinolone antibiotika och misstänker en motsatt reaktion, blick upp de video "Video Bar" på video stången, och denna plats: www.favc.info

Hvis du tager et fluoroquinolone antibiotikum og mistænker en ugunstig reaktion, udseende op de videoer på videoen stangen, og dette sted : www.favc.info

Jos otat fluoroquinolonen antibioottia, ja epäilee nurjaa reaktiota, etsii nuo videot videobaarissa, "Video Bar" ja tämä paikka: www.favc.info

Εάν έχετε πάρει μια fluoroquinolone αντιβιοτικά και ύποπτων η παρενέργεια, εξετάσει τις βιντεοταινίες σε βίντεο bar, και αυτό τόπο: www.favc.info

もしfluoroquinolone抗生物質を取って、拒絶反応を疑っていれば、ビデオバー〔棒/法廷〕と、このサイトのそれらのビデオを調べてください：www.favc.info

如果你在送一種 fluoroquinolone 抗生素和懷疑一種不利的反應，查閱那些關於視訊的條，本網站的錄像：www.favc.info

यदि आप ले रहे हैं और एक fluoroquinolone प्रतिजीवाणु प्रतिकूल संदिग्ध प्रतिक्रिया में देखना शुरू करने पर उन वीडियोज़ वीडियो बार, और यह स्थान: www.favc.info

Ha ön figyelembe véve a fluoroquinolone antibiotikum és a gyanús egy nemkívánatos reakció, felnéz a videók a video bar, és ez a hely: www.favc.info

Ако сте като на fluoroquinolone антибиотичните и съмнителни неблагоприятна реакция, проверявам тези клипове на видео бар, и този сайт: www.favc.info

Pokud jste přijetím fluoroquinolone antibiotického a podezření na nežádoucí reakce, pohle�e až ty videa o video bar, a to stránkách: www.favc.info

Indien u neemt een fluoroquinolone antibioticum en een ongunstige reactie verdenk, blik op die video's op de videobar en deze plaats: www.favc.info

Hvis du tar et fluoroquinolone antibiotikum og frykter en ugunstig reaksjon, titt opp de videoene på videoen bar, og dette stedet : www.favc.info

Se toma um antibiótico de fluoroquinolone e suspeita uma reacção adversa, olhar para cima esses vídeos na barra de vídeo, e este local: www.favc.info

Ako ste preuzimaju fluoroquinolone antibiotika i sumnja da je negativnih reakcija, gledati one video video Bar, i ovaj sajt: www.favc.info

If you are alan fluoroquinolone antibiyotik ve şüpheli bir olumsuz tepki, başınızı bu prodüksiyon on the video bar, ve bu site: www.favc.info

만일 당신이 취하고 있는 용의자 fluoroquinolone 항생제와 반응하는 부작용이 사람들을 찾는 비디오 동영상을 표시줄, 이 사이트: www.favc.info

ADR nightmare from Paul C sent to my Email.

Copied and Posted with his permission. Unedited:

Floxin Horror Chronology in Brief

Paul C

April 1998: was prescribed 10 days Floxin, 300 mg. 2/day

10 days

Day 11: woke up both ankles swollen

inflammation increased daily within both tendons/calves

Met with Podiatrist

Tried to Meet with original Dr. Again/emergency Told cannot see me without appointment...

Saw other dr. in his office. Was told I have Ryders Syndrome/Lyme Disease

Called Johnson and Johnson: told to rest.. No help\

Saw other Podiatrist... did not know what was happening

Doctor in Podiatrist office gave me Lyme disease med. Without confirmation of lyme disease.

New Lyme specialist at Hosp. Of Spec Sugergy: told NO

Lyme disease

Saw Rhymatologist Hosp spe. Sug: said it was like a baseball bat hit my legs.... I was crying in pain.

Went to surgery area Hosp. Spe surg: told to walk but no

pounding activity

few days later: 2 ruptures in 2 tendons

Was put in hard CAST for one month

Incredible Pain.... Cyring at home ttype of pain

In legs swelling but in cast and told not to take cast off

and use ice.. Which would have been smart... best doctors

in NY did not treat this correctly. 1998

While at home... found sympathetic chiropractor in CA

I talked with every day to keep me going.

Physical Therapy for 6 months

OPERATION 1999

Tumor developed behind toe of right foot.

Morton’s Neuroma Surgery 1999: Dr. Waller

More phy. Therapy: hand problems developed

Dr. Wolffe sports Phy. Therapy carpal tunnel

1999: Intence pain in both calves continued.

Saw Dr. Pfaffle, Madison Medical Group.

Intense Pain both legs Put me on steroids and Pain Meds

1999 saw Dr./ Rho Lenox Hospital

Intense terrible pain both calves ongoing. Torturous

Did EMG exam in both legs... so painful.. Nerves

damaged... hit doctor to stop test !

Test revealed autonomic nerve damage.

Tried various meds and acupuncture... no help.

Continued to work with pain meds.... Flexible

schedule.

Series of misunderstanding my doctors:

Dr. Waller Morton Neuroma surgery: pressed down

on tendon hard to test me... I screamed in pain... this still hurt? HA then he said.. If u take pain meds... need more and more you know... Then how do I deal with pain?

He also once said when I asked him in 2002 about

constant leg pain 24/7: he said I just have to relax.

No affirmation of extreme damage I’m suffering from.

Saw Urologist of friends who prescribes Levaquin: suggested I just take Citrocal 2/day. And I’d be fine.

"I know a woman with bad legs.. One month vitamins

and she was fine. "Did she have quinolone damage?" NO !!

In a desperate state in 2000:

Went to "Friends in Deed" a crisis center in NY for primarily cancer victims

Referred to pain doctor: Dr. Alan Leff

2006 MRI left and right feet: tendon tears still evident in

both legs and numerous sections of calves with fluid retention problems, tendinopathies, etc.

2006: Just could not work anymore.

Long term disability began 2006

2007: Spontaneous Tendon Rupture in Right Elbow area.

Treating that now as well.

Rhymatologist and Endocrinologist reports 2009

Low Growth Factor from Pituitary found

MRI showed small pituitary: shrank?

Low Bone density

Low testosterone

Hypoglycemic. High Blood Pressure... Weight Gain

Vit D deficiency

Chronic Hands swollen.

Possible rhymatoid Arthritis set in./ Memory Problems

Concentration Problems...

This is the tip of the iceberg of how my life has been

ruined by one 10 day course of an antibiotic

References concerning Medications causing mitochondrial diseases, altering or DNA deletions and cell apoptosis. These can manifest as fatigue, exhaustion, allergies, diabetes, heart failure, and a multitude of other diseases including those for which there are no tests available. Meds cause DNA mutations, in most cases causing ill health!

To see several posts on mitochondria and medications visit:

http://noquinolones.proboards58.com./index.cgi?board=medscience

http://noquinolones.proboards58.com./index.cgi?action=display&board=theories&thread=318&page=3

NB. Several other threads concerning cell apoptosis, mitochondrial damage, cell damage etc...


When at cellular level, and causing damage to ATP/ADR conversion, there is only one test that will show pathology. The test is only available at a private lab. It will take years for the test to become mainstream. This is purely political, and would further denigrate Big Pharma.

ADRs symptoms are denied by doctors as being "rare", causing even more despair and distress to patients. Overall, it is an uphill struggle with medical professionals. Widespread denial and collusion perpetuate the myth that Adverse Drug Reaction are "rare"... far from it. Most people do not make the correlation with a prescribed or over the counter drug they took. Often, there are delayed reactiions, and that could sometime, up to two years, whilst auto-immune illnesses for instance can take years to develop.

Unaware for instance that Aspirin can trigger tinnitus, or some prescribed diuretics can trigger diabetes? Read on:

An excellent article concerning medications affecting mitochondria This is totally different from hereditary mitochondrial diseases.

"Medications have now emerged as a major cause of mitochondrial damage, which may explain adverse reactions......"

http://www.montanaim.com/pubs/Medication-induced_mitochondrial_damage_and_disease.Neustadt-Pieczenik.pdf

For those interested in the correlation between mito cytopathies and meds, and there is a correlation between these two.

Worth noting that often those cytopathies manifest themselves, months to years later. (On a personal level, I can't take meds, even if I wanted to, and I don't, because the mito is already severely affected!! I simply could not be more iller, barely hanging by a thread as it is). In justification, honest MDs have met, have told me more or less not to take any meds, and if having to as in life/death situation, to take minute dosage and increase over a period of several months..

This may explain the overlap with ADRs to meds, vaccines, CFS, GWVs, floxies etc... Those who are severely affected, suffer similar symptoms and disease process.

This reminds me, that someone in a local support group, with severe CFS, developed stomach cancer. Before passing away, he told us that severe symptoms from CFS were far worse than his cancer. I suspect that he too suffered from an ADR...

Medication-induced mitochondrial damage and disease.
Neustadt J, Pieczenik SR.
Montana Integrative Medicine, Bozeman, MT 59718, USA. drneustadt@gmail.com

Since the first mitochondrial dysfunction was described in the 1960s, the medicine has advanced in its understanding the role mitochondria play in health and disease. Damage to mitochondria is now understood to play a role in the pathogenesis of a wide range of seemingly unrelated disorders such as schizophrenia, bipolar disease, dementia, Alzheimer's disease, epilepsy, migraine headaches, strokes, neuropathic pain, Parkinson's disease, ataxia, transient ischemic attack, cardiomyopathy, coronary artery disease, chronic fatigue syndrome, fibromyalgia, retinitis pigmentosa, diabetes, hepatitis C, and primary biliary cirrhosis.

Medications have now emerged as a major cause of mitochondrial damage, which may explain many adverse effects. All classes of psychotropic drugs have been documented to damage mitochondria, as have statin medications, analgesics such as acetaminophen, and many others.

While targeted nutrient therapies using antioxidants or their precursors (e. g., N-acetylcysteine) hold promise for improving mitochondrial function, there are large gaps in our knowledge. The most rational approach is to understand the mechanisms underlying mitochondrial damage for specific medications and attempt to counteract their deleterious effects with nutritional therapies.

This article reviews our basic understanding of how mitochondria function and how medications damage mitochondria to create their occasionally fatal adverse effects.

Delivery of Drugs and Macromolecules to Mitochondria

This article is indicating how many miles scientists have to go yet, how difficult it is to repair things at cell level in the human body. Abstract Mitochondria is where the bulk of the cell’s ATP is produced. Mutations occur to genes coding for members of the complexes involved in energy production. Some are a result of damages to nuclear coded genes and others to mitochondrial coded genes. This review describes approaches to bring small molecules, proteins and RNA/DNA into mitochondria. The purpose is to repair damaged genes as well as to interrupt mitochondrial function including energy production, oxygen radical formation and the apoptotic pathway. Keywords: Mitochondrial DNA, Mitochondrial disease, Translocators, Protein and RNA import, Membrane insertion, Lipophilic cations Full text: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2267434 http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2267434&blobtype=pdf For those who are keen on taking antibiotics, read about mitochondria cytoxicity, which meansm, essentially, DNA damage. There are several articles posted on the FAVC, http://noquinolones.proboards.com/index.cgi?board=theories&action=display&thread=318&page=1 worse offenders are, antibiotics, (Fqs, macrolides, tetracyclines, clyndamicin, Rifamopin) anti-depressants and NSAIDs.. This study is well designed and discusses glycation, cell death, lactic acidosis etc.. It mentions about high dose of these. I have yet to come accross a published paper about the toxicity of low dosage of Fqs or any other meds, LOL. It is known, that many who took just ONE lariam or Fq, or Diclofenac, have died of sudden cardiac death, triggered by cardiac electrical conductivity dysfunction, caused by a med!! http://aac.asm.org/cgi/reprint/AAC.00729-05v1.pdf Well illustrated and easy to read article re: mitochondria and its role in disease processes. http://www.ceri.com/mito.htm A lecture from Professor Leona Samson at MIT. Over my head, but, there were a few interesting facts. Watch the vid here: How much progess since this lecture in 2006?? Forget cigarette smoking (well, not completely). The really bad news, says Leona Samson, is that by virtue of the act of living, a human body will be exposed to destructive threats from the environment, and from within itself. Charbroiled burgers, sunlight, pollution, and even how our bodies use oxygen all pose what Samson calls “insults” to the DNA of our cells. Our success in fending off these inevitable DNA-damaging agents in the environment depends a lot on inheritance, Samson tells us. For instance, victims of the rare disease Xeroderma pigmentosum don’t have the capacity to repair DNA that’s been corrupted by UV radiation from the sun. Children with Xeroderma pigmentosum develop skin cancers. In the larger population, such cancers tend to occur much later in life. The reason, Samson says, is that most of us have a formidable array of mechanisms within our cells for detecting and mending defective DNA. Cells with flawed DNA that goes unrepaired must either die, or go on to mutate in often dangerous ways. Samson wants to figure out how to protect cells against carcinogenic effects in the environment, and whether a tumor cell will be susceptible to treatment. She has been painstakingly studying the Saccharomyces cerevisiae yeast organism, trying to identify all the factors that determine whether or not DNA damaging agents kill or mutate cells. She interrogated each of this organism’s 5,800 genes, “asking one by one, which of you is making a product that’s important to helping a cell recover from damage.” In what was a “huge surprise,” Samson learned that there are more than 2,000 gene products involved in helping a yeast cell repair itself, “from areas of the cell never suspected before for being important” in this way. Now Samson must elucidate the complex cellular pathways that “talk to each other” when DNA is damaged -- and figure out “how to extend to humans, ultimately.”

Interesting article concerning the connection between ion channels in the brain, and dysfunction of these causing CNS symptoms, yet, BIG PHARMA continue to manufacture "happy pills' which do not work, except for a a few hours, are addictive and cause even more damage to the fragile system of neuronal circuitry. After all, anti-depressants alone, is worth a revenue of $40 billions a year!!

Not only, there is no science behind the production of anti-depressants and most strong analgesics, such as Neurotonin, (which are nothing more than mind altering drugs), but, BIG PHARMA is jumping on the gravy train, preparing to manufacture "drugs" to treat dysfunction in potassium ion channels, hum, can't wait to see the results.

Key Potassium Ion Channel Modulating Proteins Discovered

New York (MedscapeWire) Feb 8 — A family of proteins has been identified called potassium channel interacting proteins (KChIPs) that associate with and regulate the activity of certain potassium ion channels, called "A-type" channels, according to a study in the February 3 issue of Nature. These A-type potassium channels are thought to be involved in the control of the electrical signals of the brain and other excitable tissues. Abnormalities in the electrical signals of these tissues may form the basis for a variety of disorders including anxiety, depression, ischemia, and epilepsy.

The article believed to be the first publication to identify a modulator of the function of these key potassium channels. Prior to this discovery, the activity of the isolated channel was found to be significantly different from the natural activity measured in the brain. These KChIPs are believed to be important missing components of native A-type potassium channels which helps explain the difference. The identification of these additional components may allow for the development of new drug screens to identify compounds that modulate A-type potassium channels in a tissue-specific manner. This may allow for the development of therapeutics for CNS disorders that do not cause unwanted adverse effects in nonbrain tissues such as the heart.

Cont/...

http://www.medscape.com/viewarticle/411593

NeuroPsychiatric Symptoms from Fqs & Lariam

Some of you may be suffering from Neurospsychiatric (CNS) symptoms from Lariam or fluoroquinolones antibiotics, or other meds, including, anesthetics, both local and general anesthetic. These can manifest as very mild, moderate or very severe

Symptoms vary including, insomnia, anxiety, so called panic attacks, psychosis, hallucinations and more.

From what I read so far, CNS symptoms causes distress to many and it is important to understand and try rationalize what is happening. It is temporary, and will subside, for those who abstain from psychotropics.

My own personal view is to abstain from psychotropics no matter how severe, whilst ensuring 24 hour care if suffering from psychosis and hallucinations.

When first experiencing those symptoms, it is important to realize, that these are chemically induced. It is difficult to understand the switch from being perfectly healthy to sudden waves of overwhelming symptoms, which are often denied or attributed to anxiety and stress.

Many suffering very severe symptoms, chose to endure those symptoms opting out of psychotropics, known to cause even more damage with prolonged usage. It is also known, that worsening can occur within days of starting on some psychotropics, and certainly, long term usage, for the most part lead to tolerance level, creating a vicious cycle of worse neuropsychiatric symptoms.

Many chose to opt out of psychotropics allowing for new neural circuitry to occur, without taking psychotropics. Some recover within months, for some, it may take a few years between cycles.

There may be some lingering symptoms such as cycling insomnia, anxiety, etc... These can be controlled by observing strict diets, avoiding foods which are classified as excitory, yoga, meditation, Neurofeedback, certain vitamins and supplements, and learning how to cope with stress and symptoms.

Many will suffer not quite understanding what is happening, or believe themselves to becoming "mentally" ill, which could not be further from the truth.

The effects of these drugs are known to cause damage to neural circuitry, GABA receptors (and others), 5-HTP3 and other receptors, potassium ion channels, catecholamines, hormones, adrenals, and sometimes, heart, liver and kidneys.

Although there are several herbal remedies, either from phytomedicine, Ayurvedic medicine, and Traditional Chinese Medicine, my own view, would be to abstain, from those until there is improvement, unless, thoroughly researched under a care of a qualified practitioner. Some prefer to consult neuroscientists and psychiatrists practicing alternatives using vitamins, supplements such as amino acids, and other therapeutic protocols, such as orthomolecular, successfully.

Apart from neurotransmitters, there other factors contributing to medications causing CNS symptoms, such as ion channels. It is known that meds such as mefloquine/lariam, quinine, chloroquine, (and psychotropics) causing chaos to receptors in the brain. This article focuses on 5-HTP3 receptors.

I will post another article about potassium ion channels tomorrow. It is a fragile system, and any drug targeting neuronal circuitry will have some effect on potassium ion channels, leading to more CNS symptoms. Adding to that, drugs crossing the BBB!!

The article mentions drugs to be manufactured to target those physiological electrical signals, Mmm, as IF... AS far as I know, the best remedy is time to allow new neuronal cricuitry (neuroplasticity), which takes time, but does occur.

Ever wondered why they are not dishing out pyschotropics to strokes patients?? Beware, and research before taking any psychotropics drugs. To date, there is no scientific evidence of how psychotropics work!!


The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT3 receptors
A J Thompson,1 M Lochner,1 and S C R Lummis1*
1Department of Biochemistry, University of Cambridge, Cambridge, UK
*Author for correspondence:
Received November 1, 2006; Revised January 3, 2007; Accepted January 5, 2007.

Abstract
Background and Purpose:
The antimalarial compounds quinine, chloroquine and mefloquine affect the electrophysiological properties of Cys-loop receptors and have structural similarities to 5-HT3 receptor antagonists. They may therefore act at 5-HT3 receptors.

Experimental Approach:
The effects of quinine, chloroquine and mefloquine on electrophysiological and ligand binding properties of 5-HT3A receptors expressed in HEK 293 cells and Xenopus oocytes were examined. The compounds were also docked into models of the binding site.

Key Results:
5-HT3 responses were blocked with IC 50 values of 13.4 μM, 11.8 μM and 9.36 μM for quinine, chloroquine and mefloquine. Schild plots indicated quinine and chloroquine behaved competitively with pA 2 values of 4.92 (K B=12.0 μM) and 4.97 (K B=16.4 μM). Mefloquine displayed weakly voltage-dependent, non-competitive inhibition consistent with channel block. On and off rates for quinine and chloroquine indicated a simple bimolecular reaction scheme.

Quinine, chloroquine and mefloquine displaced [3H]granisetron with K i values of 15.0, 24.2 and 35.7 μ M. Docking of quinine into a homology model of the 5-HT3 receptor binding site located the tertiary ammonium between W183 and Y234, and the quinoline ring towards the membrane, stabilised by a hydrogen bond with E129. For chloroquine, the quinoline ring was positioned between W183 and Y234 and the tertiary ammonium stabilised by interactions with F226.

Conclusions and Implications:
This study shows that quinine and chloroquine competitively inhibit 5-HT3 receptors, while mefloquine inhibits predominantly non-competitively. Both quinine and chloroquine can be docked into a receptor binding site model, consistent with their structural homology to 5-HT3 receptor antagonists.

Keywords: 5-HT3 receptor, Cys-loop receptor, binding site, ligand docking, malaria, quinine, chloroquine, mefloquine, antagonist.....

Conclusion

Cont/.....

In summary, we have used a combination of electrophysiology, ligand binding, homology modelling and simulated docking to define the mechanisms by which quinine, chloroquine and mefloquine inhibit the 5-HT3 receptor response. Our observations further extend the number of receptors known to be affected by these compounds and the growing diversity of targets may account for the broad spectrum of side effects that have been reported by patients receiving them (Luzzi and Peto, 1993; Palmer et al., 1993; Taylor and White, 2004). Inhibition of the 5-HT3-mediated current could have wide-ranging effects in the nervous system, as 5-HT3 receptors can modulate a variety of neurotransmitter responses such as those to GABA, dopamine and cholecystokinin (Thompson et al., 2006b).

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1994240

Those vids make it clear there is no scientific evidence about psychotropics efficacity, nor its mechanisms. The third vid is a good anaylysis, although not in depth.

A must see blog with excellent and articulate articles about the Pharmaceutical Industry, Levaquin and more. See http://www.levaquinadversesideeffect.com/ The blog is authored by Pharmrep8 from www.favc.info whose moving struggles can be seen on a You Tube Vid - scroll down from here, to the bottom of the page. Many thanks to Pharmarep8 for his valiant efforts to bring this tragedy to the attention of the media.

Vitamins & Supplement Individualized Protocol

Pre-ADr, there were no problems with taking Vits & Supps. Post ADR, multiple allergies/reactions. Fluctuate, change and unpredictable. What can be ingested at any given moment, might not be a few hours later or the following day.

Since June 2008, an indivdualized Vits & Supps protocols following tests and investigations. This will prepare for more aggressive detox program. I devised my own protocol based on intense/focused research.

More recently,individualized treatment protocol based on blood tests, devised by a Functional Medical Doctor and an Ayurvedic practitioner.

It takes weeks and months to try any of those. Starting with the smallest possible crumb or grain, upping dosage. Reactions are varied. Although, I bought all vits and supps as mentioned below, they have not all been "tried" yet. (NTY)and some "not tolerated." (NT).

Next posts, will focus on methylation/Krebs cycle, epigenetics and detoxing separately. Will also write for supps for CNS symptoms (or whilst weaning of Anti-depressants and other meds, which can also cause CNS symptoms, such as Thyroxine, HRT etc..

A word of caution, DO NOT TAKE vits and supps unless needed. These can alter DNA, either helping or causing harm!!

Field Treatment

Vit D3 25000 IU
RLX Metarelax
(different salts of magnesium, bought it, (NTY)
L-Arginine
(prescribed but not taking this. It can trigger shingles. Instead, I
will be taking Citrulline. This is for elevated uric acid.
Chromium (NTY)


Fatty Acids

Mega GLA Complex (NTY)
EPA/DHA sourced from algaes - farmed organically in France & Switzerland.
there is only one company in the world at present doing this. Powerful
anti-inflammatory.


Glandular Support Treatment

L-Thyroxine 2 ug daily. Fasting. (Compounded at my request)
I tried Armour once and it was too much pressure pressure on the metabolism & heart. It caused dangerous changes in EKG. Triggered arrythmia, angina pains, feeling wired, and felt ill. I may try Thyroxine later on
Bovine & Procine glandular support (NT).

Maca Inkas - Peruvian Ginseng for thyroid.(NTY).


AntiOxidant Treatment (more further down)

Vit E (mixed tocopherols formula), (NTY).
Natural Beta Carotene with mixed Carotenoids.
This brand contained Iron Oxide,which is ridiculous. I am looking for another brand.
Lutein (NTY)
Lycopene (NTY)
Zinc 50 mg daily
Selenium plus A+C+E
(Vit C 5,000 Ascorbic Acid powder)

R-Lypoic Acid (NTY)

Enzymes www.enzymedica.com

Probiotics - (NTY) not a good idea with allergies

Some of the above were prescribed by the Functional Medical Doctor. He checked and approved all.

For cholesterol, keep homocysteine at healthy level (more important than cholesterol) neuropathic pain, heart and energy.

Vitamin B1 600 mg daily (
Will swap B1 for Bentothiamine.
Vitamin B6 500 mg daily
Vitamin B12 600 mg daily
Folic Acid 800 iu daily
Niacin 100 mg daily (had to stop because of strong reaction)

Vascular, Heart, endothelial cells, Krebs Cycle, Methylation and Mitochondria

SODzyme protects against Nitric Oxide Degradation
L-Carnitine for heart, energy, mitochondria
Immuno Pro rx for heart, mitochondria, energy, immune system, raises glutathione.
Should be taken with Vit C and Selenium for synergy, Cyestine
Biotin for the krebs cycle, methylation and mitochondria
Vitamin C Rosehips 4000 mg daily
Vitamin D3 6,000 IU daily (during time of acute infections)
Vit B12 Hydroxo or Methyl (will try sublingual - NTY)
COQ10 (NTY)or Idebenone analog of Q10 (NTY)
Rutin 500 mg daily (for vascular)
Multi Minerals
Magnesium Orotate - 750 + mg daily (under the tongue) helps with heart, cellular energy, arrytmias, cramps, and more.
Mitochondria Care
cellular energy and protect against toxicity of meds:
R-Lipoic Acid, (NTY)
ALA (NTY)
NAC(NTY)
Acetyl L Carnitine,
Luteolin (NTY)
Rhodiola (NTY)
Magnesium
D-Ribose (NT))
Vitamin E (NTY)
containing Gamma tocopherol, sesame lignan extract, delta tocopherol, alpha tocopherol and beta tocopherol. Gamma tocopherol should be higher ratio. Also good for heart health.
Inositol

Cocoa polythenols
Helps reverse atherosclerosis. Cocoa helps with endothelial function.
Restore healthy blood flow, important for endothelial cells.

Eglacin acid from Pommegranates
restore healthy blood flow, important for endothelial cells.

Polycansol for cardiac health, cholesterol etc..

Manuka honey UMF 15+ but if ill with cold or infection 16 UMF+ but for MRSA infection or serious life threatening infection 30+ UMF

Serrapetase: for clogged arteries
(effective and preventive against strokes, embolism, blood clots, and cleans up atherosclerotic arteries and veins) (NTY)

Silica: For collagen synthesis: important for heart, organs, joints, bones, (NTY)

Hawthorn
heart and circulation (NTY)

Horse Chestnut
heart & circulation (NTY)

Artichokes (NTY)
to bring cholesterol down too, for liver

Hibiscus (NTY)
juice or teas to bring down blood pressure (my BP is low though)

Curcumin (NTY)
for heart failure, inflammation, digestion

Uibiquinone (NTY)
analog of CoQ 10 for heart failure, strong anti oxidant

Green Tea EGCG
to improve endolethial function now found crucial for vascular and heart health
Immune System,

Lutein, Billbery and Zeaxanthin
to protect against macular degeneration

Reseveratol
switches genes Sirt1 prolonging longetivity, warding off degenerative chronic illnesses associated with aging (NTY)

BetaGLucans (NTY)
Immune system, bacterial and viral, colds, and flu

L-theanine and lemon balm as well as green tea, help with insominia (NTY)

Added to the above, detoxing by using an Ayurvedic mix called Triphala. I checked all compounds in pharmacology journals, and phytochemistry journals.
The compounds have no known side effects, well tolerated, and effective.

Other Ayurvedic meds wre also prescribed to modulate thyroid, water retention caused by kidneys and heart failure, stomach inflammation, and a tincture for a fungal infection on a toe nail.

This will be written about in the next post.

Adverse Drug Reactions

The first post, is a concise summary of various studies concerning drug metabolism. I am highly critical of the allopathic healthcare system worldwide, the collusion amongst health care practitioners, health care providers, pharmaceutical industries, and the involvement of politicians, very often, owning majority shares in Big Pharma. With the latter spreading its tentacles further, will there be an implosion or will be it Pharmageddon?

It is an abhorrence, whenever a medical doctor throws in a caveat about alternative practitioners, whilst denying the harm prescribed drugs cause.

Moreover, I came across an article published by Swedish scientists today. It concluded that death caused by drug poisoning, is very common in Sweden. The article can be accessed here: http://www.biomedcentral.com/1472-6904/9/7

There are thousands of published articles concerning drug metabolism, pharmacokinetics, and pharmacodynamics. These articles clearly indicate that, prescribed medication is only effective for a very small percentage of the population.

Drug metabolism are dependent upon the aforementioned, and other extraneous variables. A study in Spain concludes that 6 out of 10 patients in hospital die of an Adverse Drug Reaction. This is indeed very high and is similar to studies carried out in Finland and the USA. See the article: http://www.sciencedaily.com/releases/2008/07/080707112653.htm " Individual response to small-molecule drugs is variable; a drug that provides a cure for some may confer no therapeutic benefit or trigger an adverse reaction" Nature Genetics 39, 496 - 502 (01 Apr 2007), doi: 10.1038/ng1991. Note the disparity in earlier scientific articles acknowledging metabolizing drugs is multi-factorial as opposed to more recent articles almost blaming the patients's genes.

It is simply not possible for any one single prescribed drug to be effective in most of the population. According to published articles, interpatient variability, polymorphisms, and other factors such as ethnicity, age, health status, and biochemistry involvement which we are not aware of. The fact is that whenever medication is taken, invariably, it goes into tissues and sticks to DNA adducts for a very long time. This causes genetic mutations and disease. http://jcp.sagepub.com/cgi/content/abstract/37/7/635?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=glutathione+raising&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT

There is an urgent need for a paradigm shift in medicine. Instead of aggressive chemical compounds, pharmaceutical industries should focus on restoring health, modulating pyshiological and biochemistry systems. The onus is on Big Pharma to "Do No Harm."

Although, this is a provocative first post, the intention is prevention, and more importantly, that patients should be responsible for their own health. Always read the list of side effects and take note. You could be one of the statistically "rare" victim of iatrogenic medicine.